search is your friend. this question is answered every week in Beginners
Holdem Manager website
Poker Tracker website
Assuming you have done all the steps to configure on the HEM/PT site.....
Configure your HUD
Getting the Most out of HEM/PT
Evaluating Villain Stats
Also on 2+2:
Holdem Manager Support page here on 2+2
Poker Tracker Support page here on 2+2
These threads will offer a small little taste of the HEM/PT possibilities.
GL