I have the oddest problem with the white side of this opening:
1. e4 c5
2. Nf3 Nc6
3. d4 cxd4
4. Nxd4 e5
5. Nb5 a6
6. Nd6+ Bxd6
7. Qxd6
I'm somewhat sure this is all the nearly-100% recommended moves for white. It looks better for white to me (bishop pair, backward d-pawn to target, massive holes on d5 and d6 in black's position) and the computer says it's better for white.
But I lose this middlegame an absurd amount of the time to even and a bit lower-rated players. If I trade, I had him a development edge. If I retreat, somehow villain always seems a tempo ahead of me and the rook gets to the c-file quick enough to turn the position against me, or at least with my inaccuracies).