9 handed Live
Not much history w/ villain in this hand but seems to be fairly standard. Raises pre-flop w/ most hands he enters and remains aggressive post flop.

Villain has 720 Hero covers.
Pre-Flop: Fold, fold, villain raises to 40, folds to button who calls, Hero in BB w/ A10o calls.

Flop (125): 5 6 2

Hero checks, Villain checks, Button checks.

Turn (125): Q
Hero bets 80, Villain pauses for 10 seconds and then just calls, button folds

River (285): 10

Hero bets 100, Villain pauses counts out some chips and then says, "Raise 350 more" leaving him w/ only about another 150 behind.

Is a call profitable in a spot like this?

Fold pre. I guess you're bluffing the river? You aren't getting many Qx's to fold imo. I'm not sure how you can call the river either.

Fold pre. Check/fold to halfpot or greater on the river. Im gonna go with fold the river simply because this is rando live player and he's raising the river after being quiet all hand. He's not really repping anything sensible (maybe QT), but Im sure if you call he shows up with like 555.