Booked tickets to fly to Rome in June. But the plan is to go to Tuscany/Umbria for 5 days and then Rome for 2 days.

I am traveling with my wife and two kids (8 & 10.) The kids are good travelers, last spring we went to San Miguel Mexico (of sort of Top Chef fame) and they were great walkers until the at the time 7 year old got food poisoning.

So where is a good location for day trips in Tuscany/Umbria as a central location. Florence is a given for a trip, but really looking for a central area where we can do a number of day trips. Or if Tuscany/Umbria is a bad choice with kids, where else should I go? Plane tickets purchased, but I am flexible to where to go in Italy. I like to drive, like good food, and I have been to Tuscany before but not Rome.

I can't really answer your question, but I cannot recommend Hotel David in Florence highly enough. Amazing location, super helpful/friendly staff, reasonable rates, and good-sized rooms. The owner (Gabriele) is the man and took us up into the hills on the hotels Ape Calessino for free. The food was also delicious. I love Florence so much.