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I was thinking this last month and think it more now but as weird as it sounds I like playing with like 1 fish/regs at the table then with like 3/4 fish (most tables at plo50/100) because for whatever reason I cannot beat a table with 4 fish at it but can do well vs regs. Def doing it wrong somehow
I've thought about this a bit too and I think there's a logical reason for it. Most regs play in a fairly straightforward, predictable, and standard manner. They take lines that make sense, use logic, and you know the optimal play in many situations vs them.
Fish are erratic and illogical. When they play 70% of hands you have to worry about them having a set of 2s or two pair on a 932 flop a lot more often. Sometimes there'll be a super passive fish who check-raises you and against TAGs it is standard to get it in but vs this fish the correct thing would be to fold, so you make a mistake there. You will be donked into more in places that make no sense and you'll go "huh? hmm what does he have". Your 3bet and 4bet ranges might need to adjust to maximise your preflop edge. All of this takes time and thinking and if you're playing 16+ tables it gets harder and harder to do to do the point that you start making more and more mistakes.
I think if you were playing 4-8 tables then you would certainly do better on the tables with the fish than on those with the regs but when you pump it up to 20 tables then there's a sudden shift in your ability to adjust and all of a sudden you are making mistakes all over the place, timing out, getting frazzled, etc.