Full Tilt Poker, $0.10/0.25 Omaha Cash Games, 6 Players
Hand Converter by Pokerhand.org

Board:
Button: $100,49
SB: $69,02
BB: $65,35
UTG: $27,57
UTG+1: $18,50
CO: $163,82

Dealt to CO 5c6dAc7d

Pre-flop:
(2 folds), CO raises to $,85, Button calls $,85, (2 folds)

Flop: ($2,05) 8c2d4c (2 Players)
CO bets $1,50, Button raises to $6,55, CO raises to $17,75, Button calls $11,20

Turn: ($37,55) 3d (2 Players)
CO bets $22,75, Button calls $22,75

River: ($83,05) Qd (2 Players)
CO checks, Button bets $41,52...

Not sure what to do in this spot. Yes, playing that kind of stack OOP is not the best idea ever but i felt it was a profitable spot.

Villain plays fairly loose and I know he is capable of bluffing a draw with just air, but in bigger pots he has shown up with the nuts a lot.

I thought about leading out on the river but I thought my hand looked like a set due to my flop reraise, and i don't think he gives me credit for a strong draw because I've been playing quite tight at a loose table.

Thoughts please

I'd bet the pot on turn and shove the river

I'm not sure what merits shoving the river has, a half-decent villain will not call with worse ever. Either bet river small to induce, or check call. Never folding this river to a bet this small, this just looks so much like a busted club draw or 2p turned into a bluff.

Im betting more on the turn to make a simple decision on the river and to force him to make bigger losses when he has 65. On this river I am never folding to his bet.