Had a bad night...Dropped +6 buyins at $.5/$1. Seem to be getting coolered a lot, though I also my pEV luck was -264.

Heres my biggest lost hand. Should I just fold this flop heads up?

Flop is fine.

welcome to PLO

Im not folding that flop as played vs someone with asian in his name

lol don't mind the flop shove at all for your stacks.

... same here >.<

Almost every session of PLO I play (4 tables, ~1k hands) involves me winning or losing more than 5 buyins.

I've heard so much about the variance of this game, and I guess I saw it last night a bit. What I hadn't read about is how it seems to just sneak up on you.

Of course it's easier said than done, but don't play with less than about 40 buy-ins to your name (some would say 100)... and set a stop-loss for each session so you quit if you lose say 2 or 3 buy-ins, because you don't play your best when you're losing, even if it's just to coolers and bad beats. For the last buy-in if you really don't want to quit but you're approaching your stop-loss, either buy in short or drop down stakes. Even if I've been losing the previous day I sometimes don't play my best because I'll still be tilted, or start playing scared money, so it's a good idea to play an hour or so in a lower stakes game, win a bit at that and get your confidence back before moving back to your normal stakes. It feels like a different game and there's not so much pressure, so the negative psychology doesn't carry over.

This.

Which brings me to this question:
I'm assuming the # of hands needed to establish a winrate is extremely large.

However, I have no idea how large it is.

Glad to here this is standard. A corollary to this theorem is that when I have a losing PLO session, I lose the most at my juiciest table.

I only play PLO 5 and the tables are really soft yet I got totally slammed in the last 24 hours. Down $25. After 3 days of careful grinding I get into several spots that seemed to require shoving and wound up losing my stack 5 times.

know your villain, he is quite a big TAG (nit imo ) But i would still be sticking it in

Yupp, losing 6 BI is not more than an average bad session.
At least if you play many tables. I have been 9-tabling sh lately.