Great questions!
The truth is there aren't great answers. Bet sizing theory is still an emerging field.
The main factors are
1) The polarity of the XR range - some boards call for a nuts/air XR range that promotes much larger sizes
2) The elasticity of their range - sometimes even a very small XR will force them to fold out a lot of hands, other times their range is more price-sensitive
3) SPR
Putting those metrics into practice is not so simple though.
I'm asking a
similar question about overbets in the theory forum.