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Someone who has more experience with MTTs will have to give you the complete answer, but 50 buy-ins for the $22s sounds like it's pretty good, as long as you've been profitable playing MTTs at that level in the past.
I've had success in 45 mans and small success in 180 mans. My roi in large MTTs is negative, but 10-30% roi in smaller MTTs
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The bigger your edge the smaller your bankroll cushion needs to be. Obviously a losing player won't ever have a large enough roll.
winning gradually. 10%?