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I'm not sure about this.
Maybe if you are playing against a strong player who cbets slightly too much you may make the wrong adjustments.
If you are playing a bad calling station who checks to you on the river however, you are going to do much better betting all your value and checking back all other hands then some kind of GTO bluff/value mix.
But the thing is, here you actually have very good idea of villains weakness/spot you are exploiting. When you play against ok and especially good villains, this often isn't the case, and you would be better off just trying to play pseudo GTO in spots you aren't sure what you are exploiting.
Like I play fairly "pseudoGTO" strat preflop and OTF, with exceptions to some spots where I'm fairly sure I have an read how population plays the spot or have read on the villain. So I might choose a different flopsize or totally different flop strategy than GTO would suggest, because I think people play certain spots in certain way that enables me to do this. But this fairly limited thing OTF.
Then OTT I have a bit more spots where I'm starting to exploit, I call too much/too little in certain spots, I underbluff/overbluff certain spots with certain sizes, because I now have a better idea of villains range and how they play it in this spot, with tons of experience in similiar spots. But it's still a guessing game with these exploits and on most spots I'm still just going with gtoish gameplan.
But then when I'm getting to the river, ranges start to be so well defined, and in most spots I can super easily find pivoting questions/points in the hand/ranges that will make my decision easy. And this is where I play the most exploitative. Like you might have a spot where it's hard for villain to bluff and you can just say, "my bluffcatchers are folds unless he bluffs pairs or floats flop crazy wide", and then I just ask myself does villain do either of these things, and it's often a lot easier question than the simple "does he bluff too much here".
Or the other way around "For me to have +EV bluffspot here, villain needs to call like most of his midpairs" Then I just make assumption for that question based on stats and HUD etc, and make a decision.
But OTF these questions are way harder to make and I'm better off just playing fairly GTOish strat.