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Coronavirus Coronavirus

02-28-2020 , 10:47 PM
This is new but hasnt the common flu killed more people in this same timeframe?
02-28-2020 , 11:08 PM
Quote:
Originally Posted by ddlloo12
This is new but hasnt the common flu killed more people in this same timeframe?
The question is like asking whether Afghanistan is safer than the USA because fewer people die in Afghanistan each year. The primary reason is population size (USA 327.2M, AFG 32.2M), not the % chance of death per capita.

If the population of AFG grew 10X (the same size as the USA), it would have many more deaths than the US each year, because it has a higher number of deaths per capita (or a lower life expectancy) than the US.

Fewer people have COVID-19 than common flu. Hence, fewer deaths.

The case-fatality rate of COVID-19 is much higher than common flu. In other words, if you catch COVID-19, you have a higher % chance of death, than if you catch common flu. It is most dangerous for people who are old or have other diseases, people who are healthy and young are relatively safe.

What people and governments are concerned about is the combination of a high case-fatality rate, with a highly infectious disease.

It is still early days outside of China but take a look at the trend:


Last edited by despacito; 02-28-2020 at 11:15 PM.
02-28-2020 , 11:12 PM
"The Washington State Department of Health will hold a press briefing on coronavirus at 8 p.m. PT (11 p.m. ET). No details given."

https://mobile.twitter.com/BNODesk/s...tm_name=iossmf
02-28-2020 , 11:13 PM
don't listen to uninformed "deep state" idiots..... like the president of the United States..... listen to CDC, WHO and all kinds of other G20 governments.

when do S&P futures trade?... is it only on an exchange (including european and asian ones)? or does it trade actively OTC?

seems often right on direction for the day but seems very understated. maybe that's only when the day's movement is so strong.

alternatively, does SPY, or equivalent, trade in europe, asia and australia? i can never completely figure this out. and then if i could, never sure how the conversion works.. it's been very frustrating trying to figure this out.
02-28-2020 , 11:19 PM
I don't see how a global pandemic that started in the country that Trump has criticized more than the last 4 presidents combined is going to be seen as his fault.

If anything, I think this is probably not a bad thing for Trump because there were some signs of weakening economic numbers already and now he can blame whatever issues arise on the virus and it'll be tough to refute.

"The reason the economy sucks is because of a virus that originated in China" a pretty easy argument to make.
02-28-2020 , 11:20 PM
Quote:
Originally Posted by ToothSayer
Trump has had the best response to this crisis of any world leader.
Stop embarrassing yourself with political commentary. This sub is about making money and you're smart enough to do it regardless of a democrat hoax virus/pandemic/Bernie/rate cuts/etc...
02-28-2020 , 11:21 PM
so i did find some S&P 500 ETFs....

3140.hk... hong kong..... 21 dollars.

vusa ln.... big vanguard etf in london..... 43.42

spy is at 296 approx.....

hong kong dollar is about 1/8th us$
uk pound = 1.28 us$

so the international prices don't link just by the currency...... i'll have to dive into the prospectuses...
02-28-2020 , 11:29 PM
The issue of how coronavirus affects the US election is better suited to the politics forum. I made a thread there for discussion of how the virus will affect the US election.

Whilst the election result has implications for markets, this thread should be focused on (a) the virus and (b) markets, more so than (c) the political consequences of the virus.

We have to judge what scenarios are likely/probable for (a) before we can have an informed opinion about (c).

Discussing (c) when (a) is unclear is pointless.
02-28-2020 , 11:41 PM
Quote:
Originally Posted by Backstabr
"The Washington State Department of Health will hold a press briefing on coronavirus at 8 p.m. PT (11 p.m. ET). No details given."

https://mobile.twitter.com/BNODesk/s...tm_name=iossmf
02-29-2020 , 12:04 AM
Responding to Covid-19 — A Once-in-a-Century Pandemic?, Bill Gates, New England Journal of Medicine
https://www.nejm.org/doi/full/10.1056/NEJMp2003762

Quote:
Originally Posted by Bill Gates
In any crisis, leaders have two equally important responsibilities: solve the immediate problem and keep it from happening again. The Covid-19 pandemic is a case in point. We need to save lives now while also improving the way we respond to outbreaks in general. The first point is more pressing, but the second has crucial long-term consequences.

The long-term challenge — improving our ability to respond to outbreaks — isn’t new. Global health experts have been saying for years that another pandemic whose speed and severity rivaled those of the 1918 influenza epidemic was a matter not of if but of when.1 The Bill and Melinda Gates Foundation has committed substantial resources in recent years to helping the world prepare for such a scenario.

Now we also face an immediate crisis. In the past week, Covid-19 has started behaving a lot like the once-in-a-century pathogen we’ve been worried about. I hope it’s not that bad, but we should assume it will be until we know otherwise.

There are two reasons that Covid-19 is such a threat. First, it can kill healthy adults in addition to elderly people with existing health problems. The data so far suggest that the virus has a case fatality risk around 1%; this rate would make it many times more severe than typical seasonal influenza, putting it somewhere between the 1957 influenza pandemic (0.6%) and the 1918 influenza pandemic (2%).2

Second, Covid-19 is transmitted quite efficiently. The average infected person spreads the disease to two or three others — an exponential rate of increase. There is also strong evidence that it can be transmitted by people who are just mildly ill or even presymptomatic.3 That means Covid-19 will be much harder to contain than the Middle East respiratory syndrome or severe acute respiratory syndrome (SARS), which were spread much less efficiently and only by symptomatic people. In fact, Covid-19 has already caused 10 times as many cases as SARS in a quarter of the time.

National, state, and local governments and public health agencies can take steps over the next few weeks to slow the virus’s spread. For example, in addition to helping their own citizens respond, donor governments can help low- and middle-income countries (LMICs) prepare for this pandemic.4 Many LMIC health systems are already stretched thin, and a pathogen like the coronavirus can quickly overwhelm them. And poorer countries have little political or economic leverage, given wealthier countries’ natural desire to put their own people first.

By helping African and South Asian countries get ready now, we can save lives and slow the global circulation of the virus. (A substantial portion of the commitment Melinda and I recently made to help kickstart the global response to Covid-19 — which could total up to $100 million — is focused on LMICs.)

The world also needs to accelerate work on treatments and vaccines for Covid-19.5 Scientists sequenced the genome of the virus and developed several promising vaccine candidates in a matter of days, and the Coalition for Epidemic Preparedness Innovations is already preparing up to eight promising vaccine candidates for clinical trials. If some of these vaccines prove safe and effective in animal models, they could be ready for larger-scale trials as early as June. Drug discovery can also be accelerated by drawing on libraries of compounds that have already been tested for safety and by applying new screening techniques, including machine learning, to identify antivirals that could be ready for large-scale clinical trials within weeks.

All these steps would help address the current crisis. But we also need to make larger systemic changes so we can respond more efficiently and effectively when the next epidemic arrives.

It’s essential to help LMICs strengthen their primary health care systems. When you build a health clinic, you’re also creating part of the infrastructure for fighting epidemics. Trained health care workers not only deliver vaccines; they can also monitor disease patterns, serving as part of the early warning systems that alert the world to potential outbreaks.

We also need to invest in disease surveillance, including a case database that is instantly accessible to relevant organizations, and rules requiring countries to share information. Governments should have access to lists of trained personnel, from local leaders to global experts, who are prepared to deal with an epidemic immediately, as well as lists of supplies to be stockpiled or redirected in an emergency.

In addition, we need to build a system that can develop safe, effective vaccines and antivirals, get them approved, and deliver billions of doses within a few months after the discovery of a fast-moving pathogen. That’s a tough challenge that presents technical, diplomatic, and budgetary obstacles, as well as demanding partnership between the public and private sectors. But all these obstacles can be overcome.

One of the main technical challenges for vaccines is to improve on the old ways of manufacturing proteins, which are too slow for responding to an epidemic. We need to develop platforms that are predictably safe, so regulatory reviews can happen quickly, and that make it easy for manufacturers to produce doses at low cost on a massive scale. For antivirals, we need an organized system to screen existing treatments and candidate molecules in a swift and standardized manner.

Another technical challenge involves constructs based on nucleic acids. These constructs can be produced within hours after a virus’s genome has been sequenced; now we need to find ways to produce them at scale.

Beyond these technical solutions, we’ll need diplomatic efforts to drive international collaboration and data sharing. Developing antivirals and vaccines involves massive clinical trials and licensing agreements that would cross national borders. We should make the most of global forums that can help achieve consensus on research priorities and trial protocols so that promising vaccine and antiviral candidates can move quickly through this process. These platforms include the World Health Organization R&D Blueprint, the International Severe Acute Respiratory and Emerging Infection Consortium trial network, and the Global Research Collaboration for Infectious Disease Preparedness. The goal of this work should be to get conclusive clinical trial results and regulatory approval in 3 months or less, without compromising patients’ safety.

Then there’s the question of funding. Budgets for these efforts need to be expanded several times over. Billions more dollars are needed to complete phase 3 trials and secure regulatory approval for coronavirus vaccines, and still more funding will be needed to improve disease surveillance and response.

Government funding is needed because pandemic products are extraordinarily high-risk investments; public funding will minimize risk for pharmaceutical companies and get them to jump in with both feet. In addition, governments and other donors will need to fund — as a global public good — manufacturing facilities that can generate a vaccine supply in a matter of weeks. These facilities can make vaccines for routine immunization programs in normal times and be quickly refitted for production during a pandemic. Finally, governments will need to finance the procurement and distribution of vaccines to the populations that need them.

Billions of dollars for antipandemic efforts is a lot of money. But that’s the scale of investment required to solve the problem. And given the economic pain that an epidemic can impose — we’re already seeing how Covid-19 can disrupt supply chains and stock markets, not to mention people’s lives — it will be a bargain.

Finally, governments and industry will need to come to an agreement: during a pandemic, vaccines and antivirals can’t simply be sold to the highest bidder. They should be available and affordable for people who are at the heart of the outbreak and in greatest need. Not only is such distribution the right thing to do, it’s also the right strategy for short-circuiting transmission and preventing future pandemics.

These are the actions that leaders should be taking now. There is no time to waste.

Last edited by despacito; 02-29-2020 at 12:34 AM.
02-29-2020 , 01:27 AM
Where is Bill Gates getting his 1% from? I would snap call 1% with the given information we have now.
02-29-2020 , 01:42 AM
Quote:
Originally Posted by valenzuela
Where is Bill Gates getting his 1% from? I would snap call 1% with the given information we have now.
Are saying it's too low or too high?
02-29-2020 , 01:45 AM
I think he's saying if he was offered 1% as the actual CFR for this pandemic, he would snap accept. Meaning he thinks it's higher.
02-29-2020 , 01:52 AM
IMO we still can't nail it down. It could be as low as 1% but that would require that the number of cases that are never diagnosed exceed the number of diagnosed cases by at least 2 or 3 to 1. It could be 3-4% or even higher if this "reinfection" thing is common and highly fatal but that doesn't really sound like a real concern so far.
02-29-2020 , 02:02 AM
Quote:
Originally Posted by stinkypete
I think he's saying if he was offered 1% as the actual CFR for this pandemic, he would snap accept. Meaning he thinks it's higher.


Yes. I don’t think 1% is an awful guess but I do think it’s optimistic.
02-29-2020 , 02:08 AM
Diamond Princess data is absolute gold but there is simply not enough information.
If we had the age of everybody involved and how many of them are in serious condition after 10 days we could narrow the possible ranges of CFR effectively imo. I wonder why nobody is doing that.

Edit : The data gives that there no cases that went from not serious to serious which simply seems to good to be true so I’m just assuming that nobody is updating that.
02-29-2020 , 02:21 AM
Korean data gives me a CFR or 0,6% with low undetected cases due to agressive testing. It’s also in the first 7 days since **** got out of control so since deaths pile on during the third or even fourth week since symptoms begin it’s a safe bet that it’s higher than 0,6% .

Chinese data was running at 2% cfr, now its 3,5% and I’m estimating it will end somewhere around 5% cfr with huge underreporting bias.

Deaths recovered ratio is down to 7%. That means the death recovered ratio will meet the current cfr at the halfway point estimated by me.

Ok so this means that the original 2% of the Chinese data is actually 2,5 times higher.

That means that the original of the korean 0,6 multiplied by 2,5 gives a 1,5 CFR estimation.
If we add up the undetected bias we could go down to 1,2 perhaps ?
02-29-2020 , 02:21 AM
Quote:
Originally Posted by valenzuela
Diamond Princess data is absolute gold but there is simply not enough information.
If we had the age of everybody involved and how many of them are in serious condition after 10 days we could narrow the possible ranges of CFR effectively imo. I wonder why nobody is doing that.

Edit : The data gives that there no cases that went from not serious to serious which simply seems to good to be true so I’m just assuming that nobody is updating that.
Yeah, it would be great if all authorities involved would publish data as it rolls in. The internet ******s would instantly analyze the **** out of it and we'd already know everything there is to know about this thing. Instead we'll have to wait months for data analysts to present their likely erroneous conclusions through their spokespersons who likely don't understand what they're talking about. And we'll never see a detailed dataset.
02-29-2020 , 02:28 AM
TEHRAN- TEDPIX, the main index of Tehran Stock Exchange (TSE), rose 10 percent during the past Iranian calendar week (ended on Friday)

https://www.tehrantimes.com/news/445...s-10-in-a-week

Quote:
Originally Posted by Tehran Times
The index went up 45,640 points to 524,394 during the past week.

As reported, the indices of Bank Mellat, Bank Tejarat, Iran Khodro Industrial Group, Saipa Group, Isfahan Oil Refinery, and National Iranian Copper Company mostly contributed to the rise of TEDPIX.

As previously reported, TSE witnessed the highest ever weekly rise of its main index in the Iranian calendar week ended on January 17, which was the last week of Iran’s tenth calendar month of Dey.

The index rose 45,638 points, or 12.9 percent, during the mentioned week to stand at 399.445 points.
Truly bizarre.
02-29-2020 , 04:07 AM
Quote:
Originally Posted by despacito
The article suggests people can catch the virus twice
Imo this is just media being ******ed and spreading stupidity/fear. You don't catch the same virus twice, that's not how your immune system works. You either catch a different bug or you had it all along with symptoms improving.


Also, spanish flu data isn't worthwhile to compare to now as that time had so many other factors contributing to mass death.

-crowded ww1 hospitals naturally selecting for a deadlier virus to mass spread
-antibiotics were not invented yet leading to huge death numbers from secondary bacterial infections
-healthier people were actually dying in high numbers due to cytokine overload. something that clearly isn't the case now and is treatable. as a result...
-mortality was higher in 1918 for people in their 20s/30s than 50s/60s

Last edited by Pinkmann; 02-29-2020 at 04:23 AM.
02-29-2020 , 04:38 AM
The Contrairanian Investment Strategy:



https://tradingeconomics.com/iran/stock-market
02-29-2020 , 05:28 AM
It's not about corona, it's the irrational reaction to it:

02-29-2020 , 05:39 AM
Quote:
Originally Posted by Pinkmann
Imo this is just media being ******ed and spreading stupidity/fear. You don't catch the same virus twice, that's not how your immune system works. You either catch a different bug or you had it all along with symptoms improving.
This is my assumption too until I see a credible source (not a newspaper) saying otherwise.

Quote:
Originally Posted by Pinkmann
Also, spanish flu data isn't worthwhile to compare to now as that time had so many other factors contributing to mass death.

[1]-crowded ww1 hospitals naturally selecting for a deadlier virus to mass spread
[2]-antibiotics were not invented yet leading to huge death numbers from secondary bacterial infections
[3]-healthier people were actually dying in high numbers due to cytokine overload. something that clearly isn't the case now and is treatable. as a result...
[4]-mortality was higher in 1918 for people in their 20s/30s than 50s/60s
So I think you are addressing the Bill Gates article/stats...

Quote:
Originally Posted by Bill Gates
Now we also face an immediate crisis. In the past week, Covid-19 has started behaving a lot like the once-in-a-century pathogen we’ve been worried about. I hope it’s not that bad, but we should assume it will be until we know otherwise.

There are two reasons that Covid-19 is such a threat. First, it can kill healthy adults in addition to elderly people with existing health problems. The data so far suggest that the virus has a case fatality risk around 1%; this rate would make it many times more severe than typical seasonal influenza, putting it somewhere between the 1957 influenza pandemic (0.6%) and the 1918 influenza pandemic (2%).

Second, Covid-19 is transmitted quite efficiently. The average infected person spreads the disease to two or three others — an exponential rate of increase. There is also strong evidence that it can be transmitted by people who are just mildly ill or even presymptomatic.3 That means Covid-19 will be much harder to contain than the Middle East respiratory syndrome or severe acute respiratory syndrome (SARS), which were spread much less efficiently and only by symptomatic people. In fact, Covid-19 has already caused 10 times as many cases as SARS in a quarter of the time.
To your points:

1. Agree hospitals and medical treatment now > 1918. But capacity still big problem everywhere.

2. Disagree. Real world number of infections/deaths matter. Not a theoretical-identical-conditions-vacuum comparison. Therefore, take medical treatment as it exists in the real world at the time an outbreak occurs. Would the COVID-19 CFR be higher due to bacterial co-infection if antibiotics did not exist? I don't think I should care (unless we run out of antibiotics).

3. My understanding is cytokine storm occurs in many illnesses, including coronavirus in a minority of cases. Source: spoke to a cardiologist about this topic (note: not a virus specialist). Also read journal articles that back this up but am not a subject matter expert so I may be missing something or misinterpreting. Not trying to flex. If someone knows, or has sources, pls explain or link.

4. Not sure what your point is, can you elaborate?
02-29-2020 , 05:45 AM
Yeah I give that video a big thumbs down. Swine and Spanish flu comparisons don't really equate to today. And people know they aren't going to die, they are worried about their older relatives actually dying and the world economy.

Swine flu case fatality rate was less than 0.1%, corona virus is 10-20x that with an R0 that is equal at best and at worst 2x.

Also the swine flu didn't cause a worldwide recession while coronavirus likely will.

Spanish flu comparisons are just nonsense for reasons stated above. I'm not going after Bill Gates, I just think its important to know the specifics about the spanish flu rather than just quoting deaths/infections.


Quote:
Originally Posted by despacito
To your points:

1. Agree hospitals and medical treatment now > 1918. But capacity still big problem everywhere.

2. Disagree. Real world number of infections/deaths matter. Not a theoretical-identical-conditions-vacuum comparison. Therefore, take medical treatment as it exists in the real world at the time an outbreak occurs. Would the COVID-19 CFR be higher due to bacterial co-infection if antibiotics did not exist? I don't think I should care (unless we run out of antibiotics).

3. My understanding is cytokine storm occurs in many illnesses, including coronavirus in a minority of cases. Source: spoke to a cardiologist about this topic (note: not a virus specialist). Also read journal articles that back this up but am not a subject matter expert so I may be missing something or misinterpreting. Not trying to flex. If someone knows, or has sources, pls explain or link.

4. Not sure what your point is, can you elaborate?
1. Agree hospitals can be overwhelmed in any era
2. I'm making the argument that had antibiotics been widely available 100 years ago, that the death rate would have dropped significantly. Same with cytokine reaction treatments.
3/4. Younger/healthier people died at a higher rate in 1918 because their healthier immune systems were more likely to produce a cytokine overload, which was a huge cause of death. Clearly that is not the case today with this virus. That combined with secondary bacterial infections, also being a massive cause of death, makes any comparison to the spanish flu nonsense.

Last edited by Pinkmann; 02-29-2020 at 05:58 AM.
02-29-2020 , 05:47 AM
Found this. Hopefully it's kept up-to-date:


      
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