If you're really serious then yes, they're still worth money in the long run, but they're not as soft as they were a few years ago. It will require a lot of study work alongside a lot of play to be successful in these.
The two market leading HUD programs are Holdem Manager and Poker Tracker — both have support threads on 2+2 in the
commercial software forum, as well as their own websites/forums for detailed discussion.
GL