2-5 NL @ Rivers NY. Villain in this hand is ~mid 30s white guy and has biggest stack at table around 2200-2500ish and covers everybody by a lot. I start this hand with ~1250. He is straddling every chance and usually when he forgets to straddle he just blind raises 30 UTG and has been making hands and winning pots left and right. He made a super spew shove all in with what he claimed was Ad4d on KK4 flop when he called from blinds and it was checked to a short stack who bet ~30 on flop. There was another caller from BB who called off ~600ish with KQ and won. He claimed he didn't see BB even had cards and would never have shoved all in if he knew that. After that happened villain started being a bit more observant and trying to play tighter but is still a maniac IMO. He is ordering Coronas 3 at a time, one for him and two for other players at the table. Before this hand he is probably about 5 Coronas in and they seem to be affecting his play (not for the better IMO).
One hand we played prior to hand is question I had QQ OTB, raised a limper to 25 or 30 and villain called from the blinds. Flop is like T43 with a FD and he leads 40, I raise to 105 he calls. Turn 4, he checks I bet 125 he tank folds (claiming he had a FD). Another hand we played (before the QQ one) he blind raised (I think it was blind, I even asked him if it was blind and he said yes) UTG/EP to 25, someone calls after him, I'm next up with TT in lojack and reraise to 85$ with TT, folds back to villain who decides to look @ cards now and insta pops it to 200$. Folds to me and I eventually fold too and he tables AKo.

So this hand V straddles to 10$, two people limp in EP. I have AAx and I raise to 75$ (a bit larger than I normally would here but I expect to see at least one call and because Villain is in straddle I feel I need to raise it larger than normal because we're pretty deepstack). Now villain calls 75 in straddle, first limper calls, second limper folds. 3 way to flop of:
JTx5
checks to me, I bet 145$. Villain waits a few seconds and announces "$345, in case I get lucky" and it folds to me.

This spot is kind of frustrating. My hand is super strong but if I'm up against a better made hand I'm in pretty bad shape. The fact that I have A means he can't have NFD which I would think is big part of range if I didn't have A. I guess KQ is pretty decent part of his range or other combo draws like ATcc or 89cc or 97cc.

Any thoughts? I'll post results after some discussion if people want. Thanks for input.

Frustrating spot for sure !! I personally think folding right now is out of the question though !

You are not exactly in terrific shape against some combo draws which is why I would never raise either . No fold equity .

You also have position which is why I'm just calling here. Reevaluate all turn cards but if it bricks I'm raising all in over whatever he bets . Maybe fold if the KQ straight draw hits. Turn is going to be tough we are definitely hoping for a brick

All in, I'd rather push this hand on the flop than wait for for a turn especially when a club can kill our action

frustrating spot forsure. I think he can certainly show up with a hand like 85cc, 69cc, 74cc etc just bc hes defending a straddle. Its pretty rare to get strong hands in the straddle obvi and the fish who do it are defending wayyyyy too much.

CALL and look to call down on safe looking turns, also a club turn isnt that bad cuz you do block those and he certainly has JTo/JJ/TT/55 in his range. so if a club turns and he checks I might just jam tbh

How often is he raising his straddle? If he's doing so often I would limp to set up a l/rr here.

He wasn't getting too out of line from the straddle from my knowledge. Once he raised to 100 from the straddle (I don't recall if there was a preflop raise before him or not) and he made a speech about "in case I get lucky" flop came low cards, he bet and won the pot on flop and tabled AA. I don't think he was the type to just spaz from the straddle when people limp to him otherwise I definately would have gone for a LRR.