This is quite interesting and I've thought about this before in the past when trying to hone my 6-max LHE pre-flop strategy for SB/BTN.
If the BB will call regardless then it becomes -EV for you, but in turn just by him threatening to call he has gained EV from your fold...
It's the same problem as spite callers in SNGs and tbo I'm not really sure of the best way to tackle it. My best guess is to treat it like the Iterated Prisoner's Dilemma and use a "tit-for-tat" strategy against an awkward BB (see
this thread and
this thread).
It's an interesting problem.
Juk