Stayed in La Condesa for 10 days pre-earthquake, was legit and walked around a bunch. Could definitely see posting up there to grind/live. Uber was great as well. Also liked the food cart/truck culture mixed in, even in the posher neighborhoods there.
Only clear downside seemed to be the altitude + air (even after a week wasn't quite acclimated). There's obv. a lot of crime in the broader City, but - first night got in at 1 a.m. and in front of my AirBnB a guy walking his dog didn't even look up at me as we crossed paths (totally relaxed body language). If you don't stand out, there's probably a lot bigger $$ there for bad doers to bother.
Club America game in Estadio Azteca was nuts as well, even against a newer/non-rival team like the Tijuana Xolos.