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Personally I live in the Valley,
Try the ahi tuna sandwich at Mexicali (on Ventura). I'm a big ahi tuna sandwich aficionado, and this is the best one I've ever had. It's the only thing I ever get when I eat there, and even though I don't live in the valley, I still go back for it as much as I can. Definitely wait to sit outside. It's much nicer, and for some reason all the tables inside seem like they're at neck height.
For the best Margaritas and pretty tasty old-school Mexican food, Casa Vega also on Ventura in Sherman Oaks. Also lots of star sighting potential. The cast of Friends always used to hang out there. Fun atmosphere.
Not healthy, but Joe Peep's in N. Hollywood has the best pizza I've had in LA. This is the home of the ridiculously gigantic "5969 Calorie Pizza". Personally I like the thin crust "Blue Collar" version, which they sell like it's scrawny, but is still huge.
Can't beat Tommy's chili-cheese fries (with onions, peppers and sour cream). All the food groups are represented. It's nature's perfect food.