Merge - $0.25 NL - Holdem - 9 players
Hand converted by PokerTracker 4

MP+1: 100 BB (VPIP: 14.10, PFR: 11.13, 3Bet Preflop: 4.09, Hands: 539)
MP+2: 40.6 BB (VPIP: 42.86, PFR: 0.00, 3Bet Preflop: 0.00, Hands: 7)
CO: 100.72 BB (VPIP: 52.10, PFR: 18.04, 3Bet Preflop: 0.00, Hands: 1,015)
BTN: 116.28 BB (VPIP: 21.41, PFR: 12.95, 3Bet Preflop: 3.66, Hands: 3,486)
Hero (SB): 280.4 BB
BB: 103.2 BB (VPIP: 25.53, PFR: 20.88, 3Bet Preflop: 6.25, Hands: 682)
UTG: 52.48 BB (VPIP: 36.84, PFR: 11.58, 3Bet Preflop: 5.00, Hands: 95)
UTG+1: 415.6 BB (VPIP: 23.04, PFR: 18.79, 3Bet Preflop: 7.77, Hands: 620)
MP: 102.08 BB (VPIP: 16.37, PFR: 1.95, 3Bet Preflop: 0.20, Hands: 2,793)

Hero posts SB 0.4 BB, BB posts BB 1 BB

Pre Flop: (pot: 1.4 BB) Hero has T K

fold, fold, fold, fold, fold, CO raises to 2 BB, fold, Hero calls 1.6 BB, fold

Flop: (5 BB, 2 players) 4 6 J
Hero checks, CO bets 2.48 BB, Hero calls 2.48 BB

Turn: (9.96 BB, 2 players) Q
Hero checks, CO bets 4.96 BB, Hero raises to 14.56 BB,

I think this is good. My only thought is that the Q hits his range, so it's somewhat higher variance.

Its fine with appropriate assumptions on opponent, although you can also c/c turn and donk rivers for big size

Assumptions mainly for flop and pre

In a general sense, I think it's a good spot to bluff. Villain's range is pretty wide, probably too wide. He may be scared off by the overcard. You have a good amount of equity with the OESD and overcard.

I'm just not sure that bluffing is right against this opponent, with his 52.10% VPIP, and a nice sample size. He could be the type who peels flops really light and gives up on turns, or he could be a calling station who just never folds, so I think it depends on your reads. But in general I think it's a good spot to bluff.