Here's a lits for each platform I owned
Atari 2600: Toss up between California Games & Ghostbusters
Sega MegaDrive: NBA JAM TE
PC: Civ2
PS1: FFVIII
PS2: GTA: Vice City
Wii: Resident Evil 4: Wii Edtn
PS3: Stranglehold Collector's Edtn (tho it is the flavour of the month
), looking forward to: GTA4 & RE5.
After reading thru these lists, I cannot believe I missed out on playing Grim Fandango being a big fan of the LucasArts Adventure games (like Monkey Island & Day of the Tentacle etc.)