I have always preferred a really attacking line up. Something like:
GK
RB CB CB LB
DM
AM AM
CF CF CF
It's really good if you are up against a weaker player but against players who play the same kind of way it's just ends up in a total goalsfest.
The problem I have is that if I play too defensively then I don't create as many opportunities up front. Finding a nice balance would be good.