You open wider against player 2 and tighter against player 1. Their 3bet frequencies dictate our equity realization.
Take this example to the extreme to understand the exploit.
Player 1 folds 40% and 3bets 60%, no flats. In this case the exploit would be to only open hands that can profitably continue against the raise.
Player 2 literally never raises pre. In this case you drastically expand your opening range because you're guaranteed to see a flop and realize a good chunk of your equity.
Interesting question, but I think one thing missing is context.
If we have enough HUD hands on villains for the 3bet stat to be statistically significant (which IIRC is several thousand for 3bet) we also should have an idea of how they play postflop, which can influence our decision.