My first pick is Ozu's
Dragnet Girl. This is a silent gangster flick from the early 30s. It stars Kinuyo Tanaka as Tokiko, a fun-loving typist/gun moll, who, either intentionally or unintentionally, takes over the whole movie by the middle reel.*
Kinuyo Tanaka went on to have a long and illustrious career as both an actress and a director, and it easy to understand why after this performance. Her presence in any scene becomes the focus of attention.
And, as a special treat, here is Cyndi Lauper's review:
*afaik, the first american movie where the secretary takes control of the film doesn't come until 1944's
Phantom Lady.
I'll figure out who's next and PM him.