A year and a half ago I was playing basketball. After a point was scored, I was jogging/walking backwards towards the other basket and fell for no reason. I put out my hands to break my fall and broke my right wrist (scaphoid bone). I'm right handed
I spent 6 weeks in a cast and then 6 more in a splint/brace, but now I'm all normal. The cast held my thumb and wrist in place, so it was impossible to grab anything small, and very difficult to get a strong grip on larger things. I couldn't fold clothes. I had to learn to blow my nose with 1 hand (so annoying, really).
The cast stopped before my elbow, but it still got in the way of me bending my elbow. This meant I couldn't get a fork/spoon to my mouth with my right hand, and I couldn't reach my neck to tie a tie.
Most of my problems while in the cast were due to me having to become lefty for 6 weeks. Even so, I felt that having full mobility of both arms is something we don't realize we take advantage of so much. Like the day after I broke my wrist, I went to someone's birthday party. I couldn't hold my plate and eat the cake on it at the same time (though some girl did come feed me a few bites...). Preparing the toilet paper for wiping was weird (though maybe this depends on technique?).
But it wasn't too hard to adjust. It was kinda fun, actually. It's like everything you do becomes a puzzle you have to solve. And then you start to feel good as you get better at things. For me, also, I had just entered a school pool/billiards tournament. I played 1-handed, lefty, and actually beat someone before losing horribly. I think I may be the best 1-handed, lefty pool player in my school now...
I had also just entered a doubles ping-pong tournament, so I learned to play that lefty too. It actually wasn't so bad. The worst part was the sweating and itching under the cast. I used scissors on occasion, though it probably would have been better to just ignore it, and it is possible to learn to ignore the itching so long as you can concentrate hard enough.