and re: Run Ronnie Run, there's a hilarious moment on one of the Mr. Show DVD commentaries during a sketch with Ronnie, when either Bob or Dave says "hey, I got an idea...why don't we do a whole movie about that guy?"
Sean Penn was my first thought...was gonna guess Milk though I haven't seen it yet
then chyme's Patrick Dempsey 'chyme' led to me to Outbreak (and I've seen 21 grams twice too...Naomi Watts gives a cocaine-heavy blood donation...grrrr)