I am going to take a show so popular that 3 cartoon villains were chosen from it. The show 1st aired in 1989, & according to Ranker, 10 of the top 11 seasons were in the 1990s (1989 finished 10th).
I get the entirety of the heyday of this iconic show, which was in production for the entirety of the decade. Seinfeld didn't even air for 19 months in the '90s. Other shows have even bigger problems.
There's only 1 other show I would consider for this category, & many of you might think it's a dumb choice, so I'll go with...
The Simpsons