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Old 03-16-2021, 07:08 AM   #76
chezlaw
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Re: Medical Science for Treatment of Covid-19

Some more info is emerging. It's concern about unusual symptoms rather than number of cases which is very small.

Quote:
The head of France’s vaccination programme, Alain Fischer, has said decisions by multiple EU countries to suspend inoculations with the AstraZeneca vaccine were due to the unusual nature of the side-effects reported rather than their number.

“There have been a number of alerts from several European countries over the past few days regarding somewhat atypical thrombosis anomalies which suggests an event could happen in which the vaccine might play a part,” Fischer told French radio.

“It is reasonable, when the alerts are clearly significant – more by their atypical nature than by their number, which remains very low in relation to the number of people vaccinated – for national health authorities to be cautious,” he said.

Fischer said some vaccinated people had developed thromboses “with coagulation anomalies we are not accustomed to seeing in ‘classic’ pulmonary embolisms – platelet anomalies, a type of coagulation called disseminated intravascular coagulation, that we usually see only associated with serious illnesses.”
Quote:
In its statement advising the government to pause vaccinations, Germany’s Paul Ehrlich Institute said its experts had observed “a striking accumulation of a special form of very rare cerebral vein thrombosis … in connection with a deficiency of blood platelets and bleeding” following a small number of AstraZeneca vaccinations.
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Old 03-18-2021, 10:48 PM   #77
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Re: Medical Science for Treatment of Covid-19

Quote:
The EU's leading states are to restart their roll-out of the Oxford-AstraZeneca Covid-19 vaccine after Europe's medicines regulator concluded it was "safe and effective".

The European Medicines Agency (EMA) reviewed the jab after 13 EU states suspended use of the vaccine over fears of a link to blood clots.

It found the jab was "not associated" with a higher risk of clots.

Germany, France, Italy and Spain said they would resume using the jab.

It is up to individual EU states to decide whether and when to re-start vaccinations using the AstraZeneca vaccine. Sweden said it needed a "few days" to decide.
https://www.bbc.co.uk/news/world-europe-56440139
The whole episode has been somewhat tragic imo but the 'big' countries are resuming use of the vaccine and the rest will no doubt follow. fwiw the EMA who had always said the AZ vaccine should be used, now say it should be used!

Is there a genuine issue? Well maybe (I'd even say probably) but what doesn't and it's so small compared to the side effect of sitting on their arses.
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Old 03-30-2021, 01:54 AM   #78
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Re: Medical Science for Treatment of Covid-19

Grain of salt.




"A Guide to Home-Based COVID Treatment"
https://aapsonline.org/CovidPatientTreatmentGuide.pdf


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Old 03-30-2021, 11:53 AM   #79
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Re: Medical Science for Treatment of Covid-19

Maybe it is going on to a much greater degree than is being publicized, but it seems incredible that more scientists or top notch doctors are not concentrating on the fact that eighty year olds are at least 100 times more likely to die than forty year olds. They give general reasons but I never see precise molecular reasons that should not be too hard to find given such extreme evidence. Reasons that would likely lead to a cure or better treatments.
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Old 03-31-2021, 09:39 AM   #80
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Re: Medical Science for Treatment of Covid-19

There doesnt seem to be anything significantly intriguing of therapeutic value derived from studying the rate differences other than the obvious. That is several essential to health recovery components highly correlated to old age in eg immune system, lung function, diabetes, obesity, asthma, co morbidity, cancer, past lifestyle choices, overall quality of recovery from adversity etc all deteriorate exponentially and cumulatively enhance probability of failure a couple of orders of magnitude. I would add that people living in care facilities get exposed to greater viral loads as secondary targets of the virus than the first person that opportunistically gets it in that system. The first has a smaller viral attack initially than the ones that are already there living exposed to the release of viral particles of the earlier targets. So if older people tend to live more together with others than younger people the chances of secondary exposure is higher too leading to worse than the original attack. You get clusters of substantial failure.

Worth going over all this next even if dated still relevant

https://news.cornell.edu/stories/202...-deadly-others

"Age is one risk factor. Compared to younger patients, middle-aged and older ones are far more likely to suffer symptoms, to be hospitalized and to die. One recent analysis of Chinese data estimated the chance of death in confirmed COVID-19 cases at more than 13% for patients 80 and older, compared to about 0.15% for patients in their 30s, and virtually 0% for patients under 20. A study of early U.S. cases by the Centers for Disease Control and Prevention (CDC) had similar findings."


"Catching a low dose from someone who was mildly symptomatic on the subway may involve a lower risk of severe illness,” Pelzman said, “compared to catching a high dose from a very sick and highly contagious patient.”
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Old 04-04-2021, 08:37 PM   #81
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Re: Medical Science for Treatment of Covid-19

Were the 30 out of 18 million predisposed to get the unusual blot clots?

Quote:
The Medicines and Healthcare Products Regulatory Agency says the benefits continue to outweigh any risk.
Not for the people who died, they didn't.

https://www.bbc.co.uk/news/health-56620646
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Old 04-04-2021, 09:58 PM   #82
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Re: Medical Science for Treatment of Covid-19

US Death Clock: [From all causes - that should be obvious but wanted to state it explicitly]

https://www.indexmundi.com/clocks/in...spects%202019.

For the USA:

A person dies approximately every 11.14 seconds

Number of deaths per year: 2,830,688

Number of deaths per day: 7,755

Number of deaths per hour: 323

Last edited by Zeno; 04-05-2021 at 01:19 AM. Reason: Added [ ]
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Old 04-04-2021, 10:03 PM   #83
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Re: Medical Science for Treatment of Covid-19

Link below shows Live World Death Totals from all causes (This Year and counting)

live-world-death-totals

P.S. More than 15 million people have died so far this year.......

Last edited by Zeno; 04-05-2021 at 01:20 AM.
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Old 04-04-2021, 11:58 PM   #84
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Re: Medical Science for Treatment of Covid-19

Quote:
Originally Posted by lastcardcharlie View Post
Were the 30 out of 18 million predisposed to get the unusual blot clots?



Not for the people who died, they didn't.

https://www.bbc.co.uk/news/health-56620646
Dont know. I suspect there's somthing real because they're not finding the same presentation as for other vaccines. But in general we have to consider that:

a) could be the data is being sqeezed too hard. Can always find very significant looking common factors/effects in small result sets.

b) the potential for the problem of the illusion of a rise in occurrences of anything you make more effort to look for or measure more accurately.

Either way, at worst it's absolutely tiny compared to the UK's 150k+ deaths (plus a huge number of severe illness) from covid so far. I suspect most of them would have preferred the benefits of the vaccines over the risk.


[And as always with these things. It's simply not a concern in the UK because we all died of BSE]
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Old 04-05-2021, 01:47 AM   #85
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Re: Medical Science for Treatment of Covid-19

Quote:
Originally Posted by Zeno View Post
US Death Clock: [From all causes - that should be obvious but wanted to state it explicitly]

https://www.indexmundi.com/clocks/in...spects%202019.

For the USA:

A person dies approximately every 11.14 seconds

Number of deaths per year: 2,830,688

Number of deaths per day: 7,755

Number of deaths per hour: 323
Exactly. And so it now becomes clear if 4000 are added to that number every day due to covid because leadership was and still in many places is inept, morally bankrupt and overall criminal mfers, plus 30-40% the population is a bunch of selfish punk ignorant cowards that do not care for others, then something is very wrong.

You fix this wrong by becoming scientific and ethical about it all and by telling China who the real boss will remain forever the right way until all is united properly and starts the true epic.


Do i ever expect some loser to understand why it is still important to wear a mask even after having vaccinated? Punks that ignored math at school did it for the very same reason they fail today. Because they decided laziness is ok and settling for simplistic reasoning is enough. You got to be a little less of a punk lazy sob to realize how important patience, love, empathy and personal efforts are.

Last edited by masque de Z; 04-05-2021 at 01:53 AM.
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Old 04-06-2021, 07:53 AM   #86
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Re: Medical Science for Treatment of Covid-19

Quote:
‘Clear’ link between rare blood clotting cases and AstraZeneca vaccine, EMA official says

A senior official from the European Medicines Agency (EMA) has told an Italian daily it is “clear” that there is a link between the AstraZeneca vaccine and a rare form of blood clot but that the cause is still not known, Agence France-Presse is reporting from Rome.

“In my opinion, we can say it now, it is clear there is a link with the vaccine. But we still do not know what causes this reaction,” the EMA head of vaccines, Marco Cavaleri, told Italy’s Il Messaggero newspaper.

The official reportedly told the paper that Europe’s drug regulator would be making a statement on the issue “in the coming hours”.

The EMA said last week it expected to issue an “updated recommendation” on the shot during a meeting of its safety committee that starts today and continues until Friday.
https://forumserver.twoplustwo.com/3.../index143.html
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Old 04-14-2021, 03:44 AM   #87
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Re: Medical Science for Treatment of Covid-19

“By blocking a protein called CD14 during the early stages of COVID-19 respiratory disease, the monoclonal antibody IC14 could potentially temper the immune system’s harmful inflammatory responses to SARS-CoV-2, thereby limiting associated tissue damage and improving patients’ health outcomes,” said NIAID Director Anthony S. Fauci, M.D.

https://www.nih.gov/news-events/news...disease-begins


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Old 04-22-2021, 11:26 AM   #88
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Re: Medical Science for Treatment of Covid-19

Maybe not 100% on topic, but good science requires good data, and here is an interesting case.

"On March 1 2021, an outbreak [of an E484K variant] occurred in a Kentucky skilled nursing facility... [where] 90.4% of residents and 52.6% were staff were vaccinated."

They very carefully monitored the health of everyone, and this is what they found:

Unvaccinated Residents vs Vaccinated Residents
75.0% vs 25.4% infection rate
62.5% vs 8.5% symptomatic rate
50% vs 3% hospitalization rate
25% vs 1.4% death rate

Unvaccinated Staff vs Vaccinated Staff
29.6% vs 7.1% infection rate
27.8% vs 3.6% symptomatic rate
no hospitalization, no death in either group

https://yourlocalepidemiologist.subs...WBU0DfPZRvbLOY
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Old 04-29-2021, 06:18 PM   #89
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Re: Medical Science for Treatment of Covid-19

Quote:
Originally Posted by Zeno View Post
Link below shows Live World Death Totals from all causes (This Year and counting)

live-world-death-totals

P.S. More than 15 million people have died so far this year.......
Don't remind them. Kindly focus on covid deaths only and let it be the basis of most of all life's everyday decisions. Since they all think alike, perhaps comfort them for your own gain.

Last edited by MacOneDouble; 04-29-2021 at 06:24 PM.
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Old 05-03-2021, 08:40 PM   #90
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Re: Medical Science for Treatment of Covid-19

Forty-five minute talk by a UK Pathologist on COVID. Very worthwhile and interesting.

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Old 05-30-2021, 04:56 PM   #91
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Re: Medical Science for Treatment of Covid-19

Suppression of Early Treatment




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Old 06-24-2021, 11:57 PM   #92
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Re: Medical Science for Treatment of Covid-19

Dr. Patterson appears to have identified the cause of longhauler covid. Vasodilation due to inflammation of vascular walls caused by expression of the S1 (spike) protein by non-classical monocytes. He has had consistent success treating numerous patients with the combo therapy protocol of a CCR5 antagonist (maraviroc), ivermectin, and statins. Leronlimab could be used instead of maraviroc if it gets approved and becomes available.



Patterson's website for longhaulers.
https://covidlonghaulers.com/

FLCCC Alliance - Ivermectin
https://covid19criticalcare.com/


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Old 06-27-2021, 11:20 AM   #93
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Re: Medical Science for Treatment of Covid-19

New Bruce Patterson paper about Long Covid

Quote:
--------------------
Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) Up to 15 Months Post-Infection

https://www.biorxiv.org/content/10.1...06.25.449905v1

The recent COVID-19 pandemic is a treatment challenge in the acute infection stage but the recognition of chronic COVID-19 symptoms termed post-acute sequelae SARS-CoV-2 infection (PASC) may affect up to 30% of all infected individuals. The underlying mechanism and source of this distinct immunologic condition three months or more after initial infection remains elusive. Here, we investigated the presence of SARS-CoV-2 S1 protein in 46 individuals. We analyzed T-cell, B-cell, and monocytic subsets in both severe COVID-19 patients and in patients with post-acute sequelae of COVID-19 (PASC). The levels of both intermediate (CD14+, CD16+) and non-classical monocyte (CD14Lo, CD16+) were significantly elevated in PASC patients up to 15 months post-acute infection compared to healthy controls (P=0.002 and P=0.01, respectively). A statistically significant number of non-classical monocytes contained SARS-CoV-2 S1 protein in both severe (P=0.004) and PASC patients (P=0.02) out to 15 months post-infection. Non-classical monocytes were sorted from PASC patients using flow cytometric sorting and the SARS-CoV-2 S1 protein was confirmed by mass spectrometry. Cells from 4 out of 11 severe COVID-19 patients and 1 out of 26 also contained SARS-CoV-2 RNA. Non-classical monocytes are capable of causing inflammation throughout the body in response to fractalkine/CX3CL1 and RANTES/CCR5.
==============


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Old 06-30-2021, 10:33 AM   #94
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Re: Medical Science for Treatment of Covid-19

Article on developments for Longhaulers treatment.

https://www.verywellhealth.com/long-...-story-5189914


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Old 07-27-2021, 11:44 AM   #95
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Re: Medical Science for Treatment of Covid-19

Wall Street Journal story on why approved Covid therapies are so limited.


https://www.wsj.com/articles/covid-t...ms-11627312440


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Old 08-10-2021, 02:46 PM   #96
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Re: Medical Science for Treatment of Covid-19

Check this 6 minute viral clip out. I haven't tried to verify his claim of ADE which is a big claim.

https://twitter.com/PaintInWords/sta...352924672?s=19
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Old 08-10-2021, 04:57 PM   #97
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Re: Medical Science for Treatment of Covid-19

Debunkings ongoing
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Old 09-02-2021, 11:18 PM   #98
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Re: Medical Science for Treatment of Covid-19

kinda surprised that no one in this thread ever brought up remdesivir and wanted to talk about why the results were so mixed.
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Old 09-15-2021, 11:55 PM   #99
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Re: Medical Science for Treatment of Covid-19

Sept 2021, Lancet published study of Remdesivir

"In this randomised controlled trial, the use of remdesivir for the treatment of hospitalised patients with COVID-19 was not associated with clinical improvement at day 15 or day 29, nor with a reduction in mortality, nor with a reduction in SARS-CoV-2 RNA,” the authors concluded. “Together with previous evidence, results from the DisCoVeRy trial do not support the use of remdesivir in hospitalised patients with COVID-19 in a population with symptoms for more than a week and requiring oxygen support.”


https://www.thelancet.com/journals/l...485-0/fulltext


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Old 09-16-2021, 12:07 AM   #100
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Re: Medical Science for Treatment of Covid-19

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Originally Posted by airwave16 View Post
kinda surprised that no one in this thread ever brought up remdesivir and wanted to talk about why the results were so mixed.
I've heard charges that the study FDA went by was an adaptive study where endpoints were changed at interim looks. However, I don't know if that's accurate nor how it would have affected the p-values. IMO, it deserves an investigation.


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