PSA: To any potential reader. Take a vitamin D supplement daily. Thank you.

Dissolve the vitamin D tablet in a Gin and Tonic.

PairTheBoard

Why massive research on efficient and rapid testing resulting in millions of tests per day in US is not a reality is insanely tilting and massively devastating for the legacy of our times.

Spend God damn it 20 bil $ just for the hell of it to develop the best tests in the planet and this will then save 1 tril in economic losses forward from the bs we have going.

Even pooled testing can stop this disaster. Its math is super interesting by the way and deserves a thread of its own.

https://www.cambridge.org/core/servi...rveillance.pdf

Hogan et al. tested 2888 individual nasopharyngeal or bronchoalveolar lavage samples grouped in pools of 9 to 10. Two positive samples were identified for a positivity rate of 0.07% and only 1 false positive reading was observed.[4]
In Germany, pooled testing of 1191 samples in poolsizes between 4 to 30 samples resulted in only 267 tests required to detect 23 positive individuals (positive rate of 1.93%) with all positive samples easily identified.[6] In Germany, two pooling techniques were compared, a “routine high throughput” approach where random samples are pooled together for testing or a “door to door” approach where groups of similar people(i.e families, neighbours, etc) are pooled together for testing. While both approaches save substantial resources, the “door to door” approach was found to carry more benefit, reducing tests by 56% to 93% whereas the “routine high throughput”results in 24% to 86% less tests. In low to moderate infection levels, even a pool size of 5 would reduce the number of tests needed by 5-fold(78%). In countries with infection levels over 20%, a pool size of 10 would still result in a considerable reduction in the number of tests required (up to 50%).[1]

Anyhow, I like the builluions already spent. More of that, and let us have a vaccine before Christmas!

CytoDyn announces results of phase 2 mild/moderate Covid-19 trial for leronlimab. Statistically significant improvement in NEWS2 score (predictor for progression to serious/critical) for all patients (85) over placebo for days 3,7,14. p-values <.03 , <.02 , and 0.0223 respectively.

https://www.cytodyn.com/newsroom/pre...p-line-results


PairTheBoard

Discussions of CytoDyn's press release regarding top line results of phase 2 mild/moderate Covid-19 double blind trial of drug leronlimab.

Dr. Patterson with Dr. Yo



Dr. Been (First 15 minutes)



PairTheBoard

Interesting ... Thanks, PTB.

why we're not pooling tests is completely beyond me.

Interesting article on the problems with using mortality as the primary endpoint of trials. In the second comment at the end of the article he suggests using a Bayesian probability approach rather than a frequentist statistics approach to the interpretation of data from drug trials.

https://emcrit.org/pulmcrit/mortality-2/


PairTheBoard

Dr. Drew with Dr. Patterson and Dr. Yogendra discuss
Covid, Cancer, Rantes, Leronlimab, Aviptadil, Itolizumab




PairTheBoard

As I understand the EUA for convalescent plasma treatment, there is no doubt that it is safe. The issue is that there has not been a blind clinical trial to test its effectiveness. At first glance, it would seem that because it is safe, an EUA does no harm. But the slightly deeper problem is that an EUA makes it harder to conduct a blind clinical trial because you won't have patients who are willing to chance a placebo and who will instead clamor for the actual therapy, which they can now do because there is an EUA.

Dr. Been explains Israeli supercomputer model for what's happening in the body due to Covid-19. Also, some prospective treatments implied by the model.




PairTheBoard

I read the same prospect from the Oak Ridge Supercomputer facility. Did a bunch of research, and it seems to make sense. Covid-19 isn't a cold or flu, but a blood disease and ACE2 inhibitor.

Lung tissue grown from stem cells provides model for studying COVID-19 infection

https://www.boston25news.com/news/he...FYHFLOKDTFP2Q/


PairTheBoard

"A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic."

"D614 means the original form; the mutant form is referred to as D614G, or just G614.The coronavirus that causes COVID-19 uses its Spike protein to infect human cells. D614G refers to an amino acid mutation in this protein that has become increasingly common in SARS-CoV-2 viruses from around the world. The Spike protein (S) is a string of 1,273 amino-acids; in the original form from Wuhan the 614th of these amino acids has the chemical symbol “D” (aspartic acid), while in the mutated form, the 614th amino-acid is abbreviated “G” (glycine); so S D614G is short for “having a Spike protein with aspartic-acid at position 614 mutated to glycine."

https://www.lanl.gov/updates/sars-co...iant.php#d614g


PairTheBoard

Imperfect storm: is interleukin-33 the Achilles heel of COVID-19?

https://www.thelancet.com/journals/l...340-4/fulltext


PairTheBoard

NIH begins large clinical trial to test immune modulators for treatment of COVID-19

https://www.nih.gov/news-events/news...tment-covid-19


PairTheBoard

Researchers discovered that SARS-CoV-2 uses a second receptor called Neuropilin-1, which is very abundant in many human tissues, to enter into human cells.

https://www.genengnews.com/news/sars...t-human-cells/


PairTheBoard

Researchers found that a carbohydrate called heparan sulfate, which is found on cell surfaces, may play a critical role in the novel coronavirus’ ability to infect cells.
The findings suggest that the anti-clotting drug heparin may have potential to help combat coronavirus infections.

https://www.nih.gov/news-events/nih-...e-infect-cells


PairTheBoard

Some Covid Survivors Have Antibodies That Attack the Body, not Virus

https://us.newschant.com/health/some...ody-not-virus/


PairTheBoard

Some.

Im embarrassed for thinking this disease actually deserves any more of our time. Biology is always interesting, though so keep going i guess.

Brain Scans Show a Whole Spectrum of COVID-19 Abnormalities We Can't Fully Explain

https://www.sciencealert.com/how-cov...bs-brain-waves


PairTheBoard

'New variant' of coronavirus identified in England,


https://www.bbc.com/news/health-55308211

update as needed....

Front-line essential workers and adults over 75 should be next to get the coronavirus vaccine, a CDC advisory group says.

These include first responders, teachers, day-care staff, grocery store workers and prison guards.

See link below:


covid-vaccine-front-line-workers/