Its a pretty interesting spot from both a theoretical and exploitative perspective.
My primary concern would be betting too large on the flop, since we block so many hands that can continue.
I think I like something like betting $60-80 on the flop, with the plan of blasting full pot against a single caller twice more.
This has the benefit of putting max pressure on non-net flushes, and extracting good value against other nut lo hands without the 6 hi-straight. Not to mention potential to scoop against certain combo.