Sure.
7
8
2
2
on a 6
9
T
A
board. If villain pots it, you might want to flat if the SPR is high enough. Your hand is basically drawing to a blank river.
Say there's $10 in the pot and you have $130 effective stacks, it might be better to flat if he pots it. If you raise, you can only make it $40, and he can call with a pot-sized bet left for the river. Most cards change the nuts, and you won't know what to do when he leads into you. You've created a situation where he'll be able to apply the most pressure onto you and leave you guessing.
If you flat the bet instead, you reduce his implied odds and the amount of pressure he can apply to you on the river. If a blank does hit, he might follow through with a semi-bluff, thinking you wouldn't flat the nuts there.
A contrived example, obviously, but it illustrates the point. It also shows why position is so important. It provides more options, such as controlling the pot. If you're OOP and pot the turn here and get raised the pot, it probably wouldn't be terrible to pitch it.