If you are including botox and plastic surgery in that cosmetic estimate...
The wiki on botox is actually quite interesting:
https://en.wikipedia.org/wiki/Botulinum_toxin
Botulinum toxin (BTX) is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. It is also produced commercially for medical, cosmetic, and research use. There are two main commercial types: botulinum toxin type A and botulinum toxin type B.
Infection with the bacterium may result in a potentially fatal disease called botulism. Botulinum is the most acutely lethal toxin known, with an estimated human median lethal dose (LD50) of 1.3–2.1 ng/kg intravenously or intramuscularly and 10–13 ng/kg when inhaled.
This is a joke, right? People are voluntarily injecting themselves with this stuff for years on end?