I voted for Futurama because the title and poll disagree, but The Simpsons is superior to any of them. The problem is the Simpsons haven't been good for over a decade(almost half my life! an 18 year old reading this was too young to watch any of the good episodes), but man, from Seasons 2-7 they were as good as any show could ever hope to be. Just look at the episode list from like Season 6 and you're like "Wow I must have misremembered because it seems like all the great episodes are from this season" but then you glance at Season 3 and you realize that it's
every episode. They have several 10+ consecutive good episode runs. South Park can't go 3 episodes without dropping in something that sucks, and even the really great South Parks(Scott Tenorman, Die Hippie Die) pale compared to episodes like Last Exit to Springfield or Deep Space Homer.
I've probably seen Last Exit to Springfield one hundred times and I still laugh every time Lenny gets punched in the back of the head.
Back on point:
Trying to mix comedy with pathos requires a deft touch and as much as I like the SP guys, there's no way they could make an episode that is legitimately poignant and funny. Futurama has done that, what, 4 or 5 times? Nobody else does that, not even live action shows. Those episodes are like >50% of humanity's total output of "funny/sad".
Also, Pudge, I don't like dogs at all. They actually kind of annoy me, I'm way more of a cat person. That said, if you don't cry at the end of Jurassic Bark you don't have a soul.
NSFW unless you work at a place where it's cool for employees to break down and sob uncontrollably because a cartoon dog displays loyalty:
http://uk.youtube.com/watch?v=H25B99cyTFw&NR=1