Quote:
Originally Posted by RedQueenDream
Do 2p2ers who have researched vaccines have any strong feelings about which is best in terms of efficacy and safety of the approved ones so far?
Seems like the Oxford one is safer/more traditional and the Pfizer/Moderna ones more experimental/dangerous long term, but there were also questions over Oxford efficacy?
And are you going to get it asap/see which one and assess/avoid?
thanks
Quote:
Originally Posted by RedQueenDream
Do 2p2ers who have researched vaccines have any strong feelings about which is best in terms of efficacy and safety of the approved ones so far?
Seems like the Oxford one is safer/more traditional and the Pfizer/Moderna ones more experimental/dangerous long term, but there were also questions over Oxford efficacy?
And are you going to get it asap/see which one and assess/avoid?
thanks
I don't really agree with the notion the Pfizer's and Moderna's vaccines are more dangerous. I've seen people criticize them as hijacking your cells' machinery to produce proteins of the virus, and that this could alter your DNA or have some carcinogenic effect, but I don't know of any good evidence or even the mechanism for how they could change your cell's DNA. The Pfizer vaccine does hijack your cells' machinery to produce the spike protein, but the virus does this in a much more damaging way. And more to your question, the AstraZeneca vaccine hijacks your cells' machinery to produce the spike protein also, and does so in a way that's more invasive and involves actual DNA.
Here's a brief explanation of how they work:
mRNA ones inject mRNA encased in an envelope of fat globules into your body. The fat adheres to cells and allows the mRNA to enter the cell. The ribosomes, which are outside the nucleus, then produce the spike protein that the mRNA instructs them to. After a day or two, the mRNA deteriorates and your cells stop producing the spike proteins.
The AstraZeneca vaccine injects a chimp virus (because you have no immunity to chimp viruses) that has had its DNA modified to eliminate its replication abilities, and to include instructions to make the spike protein of the coronavirus (the same instructions that the Pfizer vaccine gives to your cells). This virus then enters your cell, enters your cell's nucleus, then your nucleus transcribes its DNA into RNA, which leaves the nucleus, and ribosomes take the mRNA's instructions and produce the spike proteins.
As you can see, both involve mRNA going into your cells to instruct them to produce spike proteins. But the Pfizer and Moderna ones really are only doing that, whereas the AstraZeneca one is also giving you a genetically modified chimp virus with foreign DNA that enters your cell's nucleus.
I guess I'll just leave it there, and say that I'd prefer to get one of the mRNA vaccines, from both a safety standpoint and an efficacy standpoint. And I think they're worthwhile to get even if you're in your twenties or thirties. There may be some people a few years from now who will have lucked out and never gotten infected from SARS-CoV-2, and who never had to get a vaccine, and SARS-CoV-2 will have become eradicated. But I think most people are either going to get inoculated—either via the virus, the mRNA vaccines, the AZ vaccine, or a subsequent vaccine. Of those four options, I'd choose the mRNA vaccine.