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Old 07-10-2020, 10:48 PM   #7851
5 south
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Re: Coronavirus

Quote:
Originally Posted by Cuepee View Post
Miami Dade mayor issues stay at home order as things spike even more out of control.

Florida Governor immediately issues statement that the Mayor's order is more a request than an order since he does not have the authority to enforce it.

sigh.
Nothing like having your legs chopped out from under you.
Resident YouTube Dr Campbell reported that 33% of Miami CV deaths are under 60.
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Old 07-10-2020, 11:15 PM   #7852
PuttingInTheGrind
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Re: Coronavirus

Quote:
Originally Posted by chezlaw View Post
fwiw the oxford vaccine is expected, if it works, to produce a strong T-cell response as well as an antibody one.

And they seem to think that taking the vaccine every year or 2 would be likely to be enough.
Britain can achieve anything if we put or mind to it. Didn't have the greatest ever empire in history for no reason.

The remainer losers are moaning at the fact that the UK opted out of the EU Covid-19 vaccine scheme. However the European Commission suggested London would be unable to take part in the plan’s governance or negotiating team. Therefore we would not have had any say in which vaccines to procure, at what price or in what quantity and to what delivery schedule.

The UK is also leaps and bounds ahead of the pathetic EU when it comes to getting a vaccine.
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Old Yesterday, 01:35 AM   #7853
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Re: Coronavirus

All hail britain
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Old Yesterday, 03:40 AM   #7854
O.A.F.K.1.1
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Re: Coronavirus

Yep all hail leaves on the track Britain.

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Old Yesterday, 05:42 AM   #7855
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Re: Coronavirus

Neurological complications of Covid-19 can include delirium, brain inflammation, stroke and nerve damage, finds a new UCL and UCLH-led study.

https://www.ucl.ac.uk/news/2020/jul/...inked-covid-19

Quote:
Published in the journal Brain, the research team identified one rare and sometimes fatal inflammatory condition, known as ADEM, which appears to be increasing in prevalence due to the pandemic.

Some patients in the study did not experience severe respiratory symptoms, and the neurological disorder was the first and main presentation of Covid-19.

Joint senior author Dr Michael Zandi (UCL Queen Square Institute of Neurology and University College London Hospitals NHS Foundation Trust) said: “We identified a higher than expected number of people with neurological conditions such as brain inflammation, which did not always correlate with the severity of respiratory symptoms.

“We should be vigilant and look out for these complications in people who have had Covid-19. Whether we will see an epidemic on a large scale of brain damage linked to the pandemic – perhaps similar to the encephalitis lethargica outbreak in the 1920s and 1930s after the 1918 influenza pandemic – remains to be seen.”

The study provides a detailed account of neurological symptoms of 43 people (aged 16-85) treated at the National Hospital for Neurology and Neurosurgery, UCLH, who had either confirmed or suspected Covid-19.

The researchers identified 10 cases of transient encephalopathies (temporary brain dysfunction) with delirium, which corresponds with other studies finding evidence of delirium with agitation. There were also 12 cases of brain inflammation, eight cases of strokes, and eight others with nerve damage, mainly Guillain-Barré syndrome (which usually occurs after a respiratory or gastrointestinal infection).

Most (nine out of 12 cases) of those with brain inflammation conditions were diagnosed with acute disseminated encephalomyelitis (ADEM). ADEM is rare and typically seen in children and can be triggered by viral infections: the team in London normally sees about one adult patient with ADEM per month, but that increased to at least one per week during the study period, which the researchers say is a concerning increase.


The virus causing Covid-19, SARS-CoV-2, was not detected in the cerebrospinal brain fluid of any of the patients tested, suggesting the virus did not directly attack the brain to cause the neurological illness. Further research is needed to identify why patients were developing these complications.

In some patients, the researchers found evidence that the brain inflammation was likely caused by an immune response to the disease, suggesting that some neurological complications of Covid-19 might come from the immune response rather than the virus itself.

The findings add clinical descriptions and detail to another recent study, which also involved Dr Zandi and co-author Dr Hadi Manji (UCL Queen Square Institute of Neurology and UCLH) identifying 153 people with neurological complications from Covid-19.* This paper also confirms the previously reported findings of a higher than expected number of patients with stroke which results from the excessive stickiness of the blood in COVID-19 patients.**

Joint first author Dr Ross Paterson (UCL Queen Square Institute of Neurology) said: “Given that the disease has only been around for a matter of months, we might not yet know what long-term damage Covid-19 can cause.

“Doctors needs to be aware of possible neurological effects, as early diagnosis can improve patient outcomes. People recovering from the virus should seek professional health advice if they experience neurological symptoms,” he added.

Joint first author Dr Rachel Brown (UCL Queen Square Institute of Neurology and UCL Infection & Immunity) said: "Our study advances understanding of the different ways in which Covid-19 can affect the brain, which will be paramount in the collective effort to support and manage patients in their treatment and recovery.”

Joint senior author Dr Hadi Manji said: “Our study amalgamates, for the first time, the clinical presentations of patients with Covid-19 neurological disease with MRI and laboratory features including, in one case, a brain biopsy.

“This now sets up a template for other researchers around the world, facilitating coordinated research to optimise the diagnosis and treatments of these complications, which to date, has proved difficult. In addition, patients are going to require long term follow up.”

The researchers were supported by the National Institute for Health Research UCLH Biomedical Research Centre, Medical Research Council, Alzheimer's Association, and the UK Dementia Research Institute.
Full study manuscript in Brain journal:
https://academic.oup.com/brain/artic...waa240/5868408

Quote:
Originally Posted by Study Abstract
Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual coronavirus disease 19 (COVID-19) neurology multi-disciplinary meeting was established at the National Hospital, Queen Square, in early March 2020 in order to discuss and begin to understand neurological presentations in patients with suspected COVID-19-related neurological disorders. Detailed clinical and paraclinical data were collected from cases where the diagnosis of COVID-19 was confirmed through RNA PCR, or where the diagnosis was probable/possible according to World Health Organization criteria. Of 43 patients, 29 were SARS-CoV-2 PCR positive and definite, eight probable and six possible. Five major categories emerged: (i) encephalopathies (n = 10) with delirium/psychosis and no distinct MRI or CSF abnormalities, and with 9/10 making a full or partial recovery with supportive care only; (ii) inflammatory CNS syndromes (n = 12) including encephalitis (n = 2, para- or post-infectious), acute disseminated encephalomyelitis (n = 9), with haemorrhage in five, necrosis in one, and myelitis in two, and isolated myelitis (n = 1). Of these, 10 were treated with corticosteroids, and three of these patients also received intravenous immunoglobulin; one made a full recovery, 10 of 12 made a partial recovery, and one patient died; (iii) ischaemic strokes (n = 8) associated with a pro-thrombotic state (four with pulmonary thromboembolism), one of whom died; (iv) peripheral neurological disorders (n = 8), seven with Guillain-Barré syndrome, one with brachial plexopathy, six of eight making a partial and ongoing recovery; and (v) five patients with miscellaneous central disorders who did not fit these categories. SARS-CoV-2 infection is associated with a wide spectrum of neurological syndromes affecting the whole neuraxis, including the cerebral vasculature and, in some cases, responding to immunotherapies. The high incidence of acute disseminated encephalomyelitis, particularly with haemorrhagic change, is striking. This complication was not related to the severity of the respiratory COVID-19 disease. Early recognition, investigation and management of COVID-19-related neurological disease is challenging. Further clinical, neuroradiological, biomarker and neuropathological studies are essential to determine the underlying pathobiological mechanisms, which will guide treatment. Longitudinal follow-up studies will be necessary to ascertain the long-term neurological and neuropsychological consequences of this pandemic.

Last edited by despacito; Yesterday at 05:49 AM.
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Old Yesterday, 05:51 AM   #7856
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Re: Coronavirus

High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms (PRE-PRINT, not peer reviewed, German study):

Quote:
COVID-19 intensive care patients occasionally develop neurological symptoms. The absence of SARS-CoV-2 in most cerebrospinal fluid (CSF) samples suggests the involvement of further mechanisms including autoimmunity. We therefore determined whether anti-neuronal or anti-glial autoantibodies are present in eleven consecutive severely ill COVID-19 patients presenting with unexplained neurological symptoms. These included myoclonus, cranial nerve involvement, oculomotor disturbance, delirium, dystonia and epileptic seizures. Most patients showed signs of CSF inflammation and increased levels of neurofilament light chain. All patients had anti-neuronal autoantibodies in serum or CSF when assessing a large panel of autoantibodies against intracellular and surface antigens relevant for central nervous system diseases using cell-based assays and indirect immunofluorescence on murine brain sections. Antigens included proteins well-established in clinical routine, such as Yo or NMDA receptor, but also a variety of specific undetermined epitopes on brain sections. These included vessel endothelium, astrocytic proteins and neuropil of basal ganglia, hippocampus or olfactory bulb. The high frequency of autoantibodies targeting the brain in the absence of other explanations suggests a causal relationship to clinical symptoms, in particular to hyperexcitability (myoclonus, seizures). While several underlying autoantigens still await identification in future studies, presence of autoantibodies may explain some aspects of multi-organ disease in COVID-19 and can guide immunotherapy in selected cases.
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Old Yesterday, 05:52 AM   #7857
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Re: Coronavirus

tl;dr COVID may have neurological complications (even if respiratory illness not severe)
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Old Yesterday, 06:08 AM   #7858
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Re: Coronavirus

Quote:
Originally Posted by PuttingInTheGrind View Post
Britain can achieve anything if we put or mind to it. Didn't have the greatest ever empire in history for no reason.

The remainer losers are moaning at the fact that the UK opted out of the EU Covid-19 vaccine scheme. However the European Commission suggested London would be unable to take part in the plan’s governance or negotiating team. Therefore we would not have had any say in which vaccines to procure, at what price or in what quantity and to what delivery schedule.

The UK is also leaps and bounds ahead of the pathetic EU when it comes to getting a vaccine.
Be UK#1 within a few years I reckon.

Emperor Cummings I.

They will write songs about him.
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Old Yesterday, 07:10 AM   #7859
Borish Johnson
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Re: Coronavirus

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Originally Posted by WollyMammoth View Post
Shut down the world... over the "cold virus"

More like economic coup attempt and War on the Middle Class.

Best post in many pages, congrats on winning dunce of the thread.
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Old Yesterday, 10:07 AM   #7860
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Re: Coronavirus

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Originally Posted by Borish Johnson View Post
Best post in many pages, congrats on winning dunce of the thread.
Allow me to throw my hat in the ring.

I hate to drudge up the mask debate again but I have some thoughts. I've never put on a mask, in fact, the idea of putting one on in any situation actually repulses me. Some security guard damn near clocked me yesterday for my abstinence.

I started to wonder why? There must be something in a certain part of the north american ethos that gives me this impulse. I'm not retarded (>110 IQ), I don't want to kill grandma, I'm not sociopathic, yet I can't bring myself to do this supposedly beneficial thing for society. Maybe some armchair psychologist can shed some light.
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Old Yesterday, 10:29 AM   #7861
nutella virus
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Re: Coronavirus

Much like people who didn't wear seat belts in the 50s. Too cool and incorrectly associating vigilance with fear. The risk/reward for masks make it a no brainer. They may barely do anything, but something is better than nothing.

Some ppl are embarrased to wear one thinking it makes them look like scared sheeple. Others are embarrassed not to wear one thinking it makes them look like selfish pricks

Last edited by nutella virus; Yesterday at 10:36 AM.
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Old Yesterday, 11:16 AM   #7862
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Re: Coronavirus

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Old Yesterday, 11:21 AM   #7863
Howard Treesong
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Re: Coronavirus

Quote:
Originally Posted by Love Sosa View Post
Allow me to throw my hat in the ring.



I hate to drudge up the mask debate again but I have some thoughts. I've never put on a mask, in fact, the idea of putting one on in any situation actually repulses me. Some security guard damn near clocked me yesterday for my abstinence.



I started to wonder why? There must be something in a certain part of the north american ethos that gives me this impulse. I'm not retarded (>110 IQ), I don't want to kill grandma, I'm not sociopathic, yet I can't bring myself to do this supposedly beneficial thing for society. Maybe some armchair psychologist can shed some light.

It's not hard. Practice in front of a mirror in the privacy of your own home.
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Old Yesterday, 11:35 AM   #7864
nutella virus
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Re: Coronavirus

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Originally Posted by Love Sosa View Post
I'm not retarded (>110 IQ)
This isn't even one standard deviation above average
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Old Yesterday, 11:52 AM   #7865
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Re: Coronavirus

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Originally Posted by despacito View Post
tl;dr COVID may have neurological complications (even if respiratory illness not severe)
Yup.

I have pointed this out a few times as it seems Covid may leave a nice set of 'scars' for those who survive it and possibly even in people who are asymptomatic.

And guess what, those scars now become your Pre-Existing conditions and if Covid becomes like the Flu (or other Corona virus like the cold) and slightly mutates and comes back year after year and you can catch it again and again, you are now catching it with the type of pre-existing conditions that make you more likely to die the next time.

Covid don't play.

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Old Yesterday, 11:57 AM   #7866
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Re: Coronavirus

the above as I have also pointed out the Trump Co, fights its hardest on behalf of Big Insurance to cancel Obama care and get rid of the pre-existing conditions protection while saying 'trust us, we will create something else much better.

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Old Yesterday, 12:03 PM   #7867
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Re: Coronavirus

I was curious about that slide that Trump used in the beginning of May to defend the statistics of CV in the USA. As a reminder:



Some stats about this graph:

China is still at 0,3, hail China!
Germany is now at 10 (x2 since this chart)
Iran is now at 15 (x2,5)
USA is now at 41 (x3,7)
Netherlands is now at 35 (x1,5)
UK is now at 66 (x3)
France is now at 46 (x1,6)
Italy is now at 58 (x1,5)
Spain is no longer reporting accurate stats
Belgium is now at 84 (x1,9)

USA evolution is by far the worst, followed by UK & Iran. USA is also now higher than NL and will surpass France in a few weeks.

USA is also now adding close to 2x number of new cases per day than Europe was at its peak (and Europe population is >2X USA).
Has Corona just been normalized in USA, or is a collapse coming? Even some of the more heavily hit states are now starting to show a 2nd wave incoming and even NY and NJ never really got their figures down to levels that some countries in Europe are achieving.

What will it take for new major action? Avg daily deaths moving back above 1k? 2k?
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Old Yesterday, 12:08 PM   #7868
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Re: Coronavirus

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Originally Posted by 5 south View Post
Nothing like having your legs chopped out from under you.
Resident YouTube Dr Campbell reported that 33% of Miami CV deaths are under 60.
And that trend will continue for a while.

You will see less deaths per million infected as the people being infected are much younger and thus less susceptible but since so many younger people, and mainly young people, are being infected a certain percent will die.


But eventually even the most careful older people and those at risk with pre-existing conditions will fall if the young people keep pushing this general infection rate up and up and up.

Eventually those at risk must go to a grocery or take a delivery or visit a doctor and the young people are slowly saturating every area with the virus making multiple contacts with it more and more certain.

Quote:
Originally Posted by Love Sosa View Post
Allow me to throw my hat in the ring.

I hate to drudge up the mask debate again but I have some thoughts. I've never put on a mask, in fact, the idea of putting one on in any situation actually repulses me. Some security guard damn near clocked me yesterday for my abstinence.

I started to wonder why? There must be something in a certain part of the north american ethos that gives me this impulse. I'm not retarded (>110 IQ), I don't want to kill grandma, I'm not sociopathic, yet I can't bring myself to do this supposedly beneficial thing for society. Maybe some armchair psychologist can shed some light.
The psychology is not unique.

It stems from the long understood view that 'those who do not learn from history are doomed to repeat it'.

That is speaking to people only being able to learn from personal experience and not the experiences of others.

Your reaction falls into that family of reactions.

Despite seeing all around you stories of OTHERS with your attitude either dying or worse, being asymptomatic and inadvertently killing family members or friends, you cannot process that information in a way that will make you take the precautions to protect yourself and others.

However if and when you do catch it and if that leads to the death of a friend or family member, then and only then, will your view change. Suddenly you will become an evangelist to others stating this is no joke, please learn from my experience.

Sadly you would be singing to a choir as those inclined to take precautions already would be. Those like you will not be able to learn from your experience.
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Old Yesterday, 12:30 PM   #7869
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Re: Coronavirus

Quote:
Originally Posted by bbfg View Post
I was curious about that slide that Trump used in the beginning of May to defend the statistics of CV in the USA. As a reminder:



Some stats about this graph:

China is still at 0,3, hail China!
Germany is now at 10 (x2 since this chart)
Iran is now at 15 (x2,5)
USA is now at 41 (x3,7)
Netherlands is now at 35 (x1,5)
UK is now at 66 (x3)
France is now at 46 (x1,6)
Italy is now at 58 (x1,5)
Spain is no longer reporting accurate stats
Belgium is now at 84 (x1,9)

USA evolution is by far the worst, followed by UK & Iran. USA is also now higher than NL and will surpass France in a few weeks.

USA is also now adding close to 2x number of new cases per day than Europe was at its peak (and Europe population is >2X USA).
Has Corona just been normalized in USA, or is a collapse coming? Even some of the more heavily hit states are now starting to show a 2nd wave incoming and even NY and NJ never really got their figures down to levels that some countries in Europe are achieving.

What will it take for new major action? Avg daily deaths moving back above 1k? 2k?
I've point this out many times as this is one of the LAST major horrid stat that the US is not #1 in and if the US really wants to be #1 in everything they can take comfort that they will soon over come.

As the US gets to the impending and now inevitable 200,000 deaths that will take them to 61 deaths per 100,000 or 610 deaths per million as we see it more commonly cited.

Some Trumpers here say 600,000 deaths is the number we should now expect and in fact was inevitable so don't blame Trump as anything below that is 'great job'.

At 600,000 deaths that is 182 deaths per hundred thousand or 1819 per million citizens.

Trump himself, if you pay attention is now saying anything short of 1-2 million deaths means 'good job him', as he tries to set that bar at a level he really hopes won't be reached so he does not have to raise it again.

That is 303 deaths per hundred thousand or 3030 per million.



You can see at 200,000 or 61 deaths per million the US has Britain in their sites and it is clear they will sprint past them. And as you move on to those next threshold you have the US building an insurmountable lead and once again proving American exceptionalism.


MURICA!!!!
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Old Yesterday, 01:10 PM   #7870
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Re: Coronavirus

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Originally Posted by Love Sosa View Post
yet I can't bring myself to do this supposedly beneficial thing for society.
you clearly don't think it's actually beneficial. not sure why. probably what cuepee said.
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Old Today, 04:23 PM   #7871
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Re: Coronavirus

26 June

Quote:
Gov. Greg Abbott keeps businesses open despite surging coronavirus cases and rising deaths in Texas

“We can protect Texans’ lives while also restoring their livelihoods,” Abbott said this week.
10 July

Quote:
Gov. Greg Abbott warns if spread of COVID-19 doesn’t slow, “the next step would have to be a lockdown”

https://www.texastribune.org/2020/06...g-abbott-open/
https://www.texastribune.org/2020/07...as-mask-order/
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Old Today, 04:25 PM   #7872
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Re: Coronavirus

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Originally Posted by Kelhus100 View Post
The first article is comparing it to flu virus, so that is completely irrelevant.
That is basically arguing one species of elephant evolves faster than other species because dolphins evolve faster.

The second article is addressing how the virus is evolving in the moment, not whether it has the capacity to evolve.

Neither of those articles addresses my point at all.

If/When there is a vaccine or effective therapeutic that inhibits the virus's ability to replicate, that will create a selective pressure, and we don't know how COVID will respond to the pressure. We are hoping it won't be able to respond at all, and we will defeat it, but I am not sure the totality of evidence suggests that is the likely scenario.
The current strain has no problem spreading thanks to the pre- and asymptomatic spread. How and why would a new strain overtake it?
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Old Today, 07:49 PM   #7873
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Re: Coronavirus

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Old Today, 08:12 PM   #7874
Kelhus100
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Re: Coronavirus

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Originally Posted by chytry View Post
The current strain has no problem spreading thanks to the pre- and asymptomatic spread. How and why would a new strain overtake it?
I mean the post you highlighted said, "If/When there is a vaccine or effective therapeutic that inhibits the virus's ability to replicate..."

So I guess that is the answer to the question.
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Old Today, 08:17 PM   #7875
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Re: Coronavirus

https://news.yahoo.com/plasma-shot-c...130023057.html

Interesting article about how we could possible be using antibodies from plasma of previously infected Covid patients as prophylactic shots that would serve the function of a vaccine and provide some level of temporary immunity.

Unfortunately, it seems although many scientists think it is a perfectly valid concept scientifically, there is no interest in exploring this option due to economic realities and inertia.
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