As for my own thoughts on this topic:
I have been going back and forth on complicated vs simplified strategy/game tree. Now after reading this thread I'm thinking it is good to study both methods, both simplifying the complicated game tree and using a simplified game tree, but in practice at the tables you should more often use the simplified game tree and try to execute as optimal as possible, especially vs opponents you play alot with, because otherwise over a certain amount of time likelihood increases of your opponents adjusting to your flawed frequencies and exploiting you, if you use the simplified version of the compliicated game tree.
However if you study more complicated game trees, from time to time maximizing ev of certain hands has to be a good idea too, you can do this even vs players you play alot with if you only do it occasionally. That way it is impossible for them to adjust.
Of course all that is assuming that in any given spot we have good ideas about various solved game trees.
This reminds me also of this video by Daniel Dvoress on Runitonce of a flop spot which goes into the topic of simplified vs more complicated strategy as well, where Dvoress makes the case for a more complicated strategy
https://www.runitonce.com/poker-trai...ng-large-bets/
I made the following comment on that video which i think fits for this discussion as well
"regarding loss of ev by following the simplified/worse strategy with the 100% small cbet vs the more complicated big bet/small bet/check strategy: Is there a way to figure out how much ev you can lose by following the more complicated strategy, but not mixing correctly (using big bets too much for example, or checking too much) and where the threashold is, like how accurate do you need to be with that in order to really gain ev over the small cbet 100% strategy, since that one is easy to follow and you cant mess up at all. I think that factor makes it not so easy to say that the more complicated strategy is better for everyone. Also i would actually bet that nobody can mix the frequencies perfectly there as used by pio. Thats why i think its important to know the margin of error that allows up to still gain advantage over the simple strategy"