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Originally Posted by Korona Killer
Too plain and overly simplistic. Can you amp up on the technical and the complexity please. But only by a little. Not as complex and technical as the first time. Thanks.
I think the video posted above is a good explanation. Basically the respiratory issue that people are dying of is called Acute Respiratory Distress Syndrome (ARDS). A syndrome is a collection of symptoms and isn’t necessarily linked to a route cause as there can be multiple. It’s basically a catch all term that defines three criteria (I) bilateral pulmonary infiltration (goo in your lungs) (ii) reduced pulmonary compliance (lungs don’t expand as much and (iii) hypoxemia (low oxygenation in the blood.
Now ARDS is usually an Exudate. Exudate means the goo in your lungs is inflammatory because it recruits immune cells (neutrophils and cytokines). And as a result the inflammation leads to scarring in your lungs and they don’t work as good and you also get atelectasis (lung collapse - but not like the entire organ like you might hear people say, that’s a pneumothorax, it’s like little bits of the sponge in your lung shrink. Apparently (and I’ve no credible sources/papers on this) what coronavirus is doing compared to someone who gets ARDS from let’s say a bacterial pneumonia is that it seems to go and directly attack the cell that produces surfactant. Surfactant is a little bit of coating around the aero bubbles in your lungs that keep them open instead of squishing into each other. So the usual treatment methods of ARDS, have to be modified to account for this so the treatment of acute episodes is not optimised.
Secondly is the cardiovascular system. It affects the ACE 2 receptor. This stands for angiotensin converting enzyme and converts a little molecule in your body called angiotensin I to angiotensin II. This angiotensin II is the active version and has a lot of downward effects in your body from constricting your blood vessels (and thus maintaining your blood pressure. To signalling the kidneys to produce a hormone called aldosterone which is an important control in your bodies intravascular fluid levels also used or maintain your blood pressure. So people who are on medication for their blood pressure either angiotensin receptor blockers (also known as -artans) and those on ACE inhibitors (drugs ending in -pril e.g ramipril) are going to be all out of whack. Additionally the virus seems to be apparently affecting the actual cardiac tissue itself also causing a cardiomyopathy in its most acute form of the disease. All these factors are what makes it fundamentally a different disease than the flu, even though the symptoms may appear similar.
Last edited by Halo_P1; 03-12-2020 at 11:40 PM.