Concerning...
Coronavirus and the brain: UMass Memorial Health Care researchers say COVID contributes to dementia, embark on federally funded study
A team of UMass Memorial Health Care doctors has embarked on a two-year study looking and whether COVID-19 triggers inflammation in the brain that in turn causes brain matter to start to break down, leading to dementia...
...We believe COVID-19 infection causes neuroinflammation, which in turn causes a decline in cognitive capability and loss of brain matter,”...
If true, Golenbock says the respiratory infection can lead to the acceleration of conditions like Alzheimer’s and Parkinson’s disease.
...Numerous studies have demonstrated that patients with severe COVID-19 who end up needing ICU care often exhibited symptoms of cognitive decline during their bout of illness. A study published by researchers at Northwestern Medicine dating back to October found that more than 80% of 509 hospitalized COVID patients had “neurologic manifestations.
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In fact, there is a growing body of evidence that neurological effects in COVID patients are more common than once thought. Episodes of delirium have been observed in critically ill COVID patients in Europe and the United States at unusually high rates — so much so researchers have thought about making part of the disease’s diagnostic criteria.
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Their primary neurological symptoms included brain fog, which was present in 81% of patients; headache, present in 68%; and numbness/tingling, present in 60%. A little more than half of the patients reported a persistent loss of taste or smell and muscle aches that involve the body’s soft tissue — tendons, ligaments, and connective tissue, according to the study.
The point of interest for the team of UMass researchers begins with one central process: inflammation. The group proposed the COVID-dementia link after learning that COVID patients can experience an exaggerated immune response to the infection called a “cytokine storm,” a potentially fatal condition of multi-system inflammation caused by the release of an excess of small proteins called cytokines that act as messengers for the immune system.
The phenomenon is also thought to have played a part in what made the Spanish flu so deadly during the 1918 influenza pandemic, according to the New England Journal of Medicine. The bacterial infection Yersinia pestis, responsible for the Black Death that swept through Eurasia in the 14th century, also triggers the overproduction of cytokines, resulting in the cytokine storm, according to NEJM.