Not only would I play him, I'd sit to his left.
Look, if he understands money and gambling enough to sit down at a poker table, then he's fair game. It's not your job at a poker table to protect people from themselves.
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However, if he cant control himself and there isnt someone to tell him when to stop, them playing with him is wrong I think.
This happens with fully-functioning people all the time. Do you soft-play them as well?