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Always sounds like Andre was just being a territorial prick.
Andre was always fearful of someone else trying to be the big man....that was really all he had going for him. He actually refused treatment for his condition because he was afraid it would interfere with his gimmick.
Anyone who even challenged his status was treated pretty roughly. Studd, Bam Bam Bigelow, and more have talked about it at one point or another.