You can tell PT4 to filter the stats basing on the number of players dealt in, but it will still be showing the same set of stats, which is uneconomical.
In order to change the set of displayed stats automatically when the game switches to HU, so that the now useless stats like BB overcall vs BTN and SB disappear and some more useful stats tailored to HU appear in their place, you do need to either use one of the commercial HUD switchers in conjunction with your existing HUD profiles, or use the
CoffeeSpins HUD profile that converts itself from 3-max to HU with no need for a switcher.