^Yeah that
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For example, two identical hand situation with the same stacksize and opponent can have completely different optimal lines based on gameflow, a feel for whats goin on at that moment.
Optimal in terms of max EV line, not GTO, then yeah sure. Though if we talk about solving the game there's always one and only line to take that is unexploitable, regardless of game flow. But for sure it's not max EV vs opponents that strongly deviate from GTO themselves, so like Hundrye said, why bother even looking for it in games vs fish when non-GTO lines will show much bigger profit.
About solivng a game vs regs and vs fish (weakly solved idea). I think that it was about the fact that game vs reg is like poker with a bit simplified rules, because some spots wouldnt ever come up (that u can see often in games vs fish), there's less chaos and game is more predictable. Thus we can say its less complex version of poker than vs fish when you basically need to know more perfect ranges, eg. when faceing some unusual sizings + lines. So imo there's analogy to extremely non-complex version of poker, well known push-fold option, that was easier to solve and its solved for some time now.