AK - General Theory Studying

So I’ve been doing quite a bit of work off the table assessing the equity of hands like AK, and in my digestion I’ve come across a few pretty general theory questions that will likely take somebody much better at poker than me to answer correctly and with relative certainty.
Essentially I’ve been spending my time trying to optimize a strategy in which I can be as aggressive with AK as possible without being too aggressive. That means looking at board textures and Villain hand ranges and figuring out the pre flop strategy as well as the 3-betting strategy, double barreling, etc.

In general I’m going to be 3-betting with AK roughly 90-95% of the time I’m given the opportunity to do so, as I don’t think that flatting in the majority of cases will be as outright profitable. If anybody has any scenarios in which flatting an open with AK is more profitable than a 3-bet long term, I’m all ears. The select cases (The 5-10% of the time) that I will be flatting AK will be occasions in which a relatively strong player opens UTG/+1 and it folds to me in either the SB or the BB. I will be doing this with less frequency in the SB obviously. I think having some calls with AK here is a great way to balance my BB completion range and I’m given the convenience of not having to isolate. I can also consider flatting when I’m on the button if I have compelling evidence that suggest that the SB and BB are very passive post flop and given that they decide to defend (usually getting a price of 3/1 to call) they’re going to be very straightforward to play against afterwards. Even then, I’m not entirely in love with that idea, as I simply think isolating will almost always be more profitable long term.

My major questions concern the concept of 3-betting AK for value. So I know that in order for the 3-bet to be classified as “for value” I have to be ahead of villains continuing range when I 3-bet. This means they need to continue with at least a range as wide as 77+/KQ+/AJ.

The questions are:

1.) If I have AKo and I’m UTG+2, facing an open-raise from Villain UTG/+1 but I know that Villain will only continue vs. my 3-bet with something like TT+/AQ+/KQ is 3-betting still the most profitable play? Is the concept of “Isolation” more valuable than playing perfectly against Villain’s range?

2.) Is there any argument for folding AK against an UTG open raise when we know that they’re playing super tight-aggressive from here (something like VPIP:7 or less) and we know that the players in late position are going to be tough to isolate?

Predictions/My Thoughts:
To question 1, I’m guessing that flatting with AK when we’re UTG+1/UTG+2 is probably not going to be very appealing - but I’m still curious.

To question 2, it’s hard for me to make any reasonable argument for letting go of AK pre to anybody in any position when all I’m facing is a standard open.