Hard for Hero to actually have specifically the 1 hand which makes a straight. Much easier for Hero to have draws. If you are just calling 2p and sets anytime any straight gets there, you are losing value. This is a "scary board" for 2p and sets not because of the slim chance of straights, which account for 16 combos, but for the 2 flush draws which account for a ton more (as many as 110? but you can discount many due to the action so far - point is its more than 16).
If you are playing against the entire range of Hero's hands, not the 16 which happen to have you beat, you are way ahead with 2p and sets. Raise for value, raise to cut the odds of the FDs and force Hero into a mistake if they call.