if you all in preflop with AA at a 1/1 fishy place. and the guy have QQ and offers to run out 2 boards, would you only run it once because you 80%, or would you run it twice to lower variance?
Run it once. I am well rolled for my games. I also want my opponents to make tough decisions for their money, and I make their lives easier by running it multiple times.
There's no answer to this question, since it doesn't effect your winrate or +EV. It simply reduces variance. If you want to avoid variance, go ahead and run it 2x (3x actually generally works better because at least psychologically and for the entertainment of the table there's a "winner"). If you don't care about variance, run it once, live with the result.