How do u generally play hand like AT/AJ or even KT/KQ...lets say someone raised early, mp1 called, and action on you.

People say generally either 3b/fold these hands because once u call, the people especially sb/bb might come along and u possibly don't know where your hand stands for the rest of the streets.

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Way too broad a question.

What position you are in matters. The AX and KX/QX have to be handled entirely differently. How good your kicker is matters. If it is suited or not matters. Action in front matters immensely, what position and who made it. Stack sizes play into it.

Agreed. Hard to answer but is there a way to think about this from a range perspective?

Generally speaking let's say someone opens FMI from UTG+2 or the LJ and we're in the blinds. Not taking into account any player specific information. Should there really be a discernable difference in how we play hands that OP mentions? Kind of seems like these hands are marginal given that they are at the bottom of the ranges were up against. Perhaps we play hands like AJo against the LJ because in that position should be raising more Ax combinations than UTG+2? We really shouldn't play any non suited broadway hands against either open.

What tools could we use to determine defending ranges against certain % opens? Flopzilla or piosolver?

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Going to lock this because it is too broad a question to answer. There are so many other variables to look at to do anything else other than to say, "it depends."