Readless on villain (been at table for less than an hour and haven't seen him showdown) but he's like a 40 year old white dude who has clearly played before. OTTH
Raise from LJ to 10 and Villain calls, BU calls, to hero in SB with AdQd calls and BB calls. I think squeezing here is fine but I'm usually calling here OOP and I'd rather use AQo as a squeeze since it plays so poorly multiway. Also, the guy who is raising in the LJ hasn't open raised before and have seen him limping. So yeah, squeezing is standard and so is flatting and that's not what I'm really worried about in this hand.
Flop: Qx8d2x rainbow
Hero checks (I think leading out is just as good or better but pot controlling is fine and I'm expecting a bet most of the time anyways). Villains bets 50 into ~50 Hero calls rest fold. Pot ~150
Turn 6 completing the rainbow. Hero checks and villain bets 200. Hero has 260 behind approximately. Hero?
It's a spot where we have to jam or fold imo. I think this spot will seem like a snapjam to most people, and I understand that, but at the same time villain never has any bluffs here so we should be way overfolding. His range is something like 22, 88, KQ, AQ or something like that and I doubt this exact player has QQ or KK or AA. The pot flop 5 ways and overbet turn is a super nutted fish line and it's hard to imagine him vbetting a worse hand (maybe KQ but I doubt that's overbetting here). If I'm not calling with this hand I'm only calling sets but against this line maybe an exploit fold isn't that bad?
Hero tanks for ~4 minutes and jams.

Not 3 betting PF and playing a 4 way pot OOP is a terrible position in my opinion. I would've 3B to 50-60 PF and.CB the flop in this case.

Tough spot you're in, I'd fold in turn here with a really ****ty feeling about it.

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Flatting pre is a big mistake - make it $50~ or more

+1

You are not flatting here to make a top pair type hand. Either 3-bet or fold when your monster hand doesn't develop. Villain is clearly not scared of top pair, you have no other real draw, it is time to fold.

Generally the flat is pretty bad here but I'd be OK with it if this guy literally has not raised PF in an hour.

As played, it's close but I'd fold. Until I see this guy show down a big bluff, I will assume he is never bluffing here, but if his value range was as "loose" as { QQ+,88,AQs,KQs,AQo,KQo } then you'd have enough equity to get it in, barely. I'm discounting KQ in his range though as he may not raise it pf and may not bet so much on the turn. His whole line kind of smells of an overpair.

This is a very standard 3b from me and I only did not because the PFR had not raised a single hand in over an hour and I had seen him open limp many many times before. Point of clarification that villain in this hand was not PFR and probably doesn't have QQ+ in his value range, which does make a pretty big difference since he is now repping a much thinner range.

Ah. My bad. I'm just ripping it in then, his range that beats us is pretty small and betting 200 into 150 with a set on such a dry board would be pretty spazzy (doesn't mean he hasn't done it, but it wouldn't be my first guess of what he has). Your hand is super under repped and he's probably certain KQ is good here, could have QJ easily as well.