Playing 1/2 Villain is a Good Reg.

Villain stack is £400ish
Hero stack is £300ish

Villain straddles to £5 I wake up with QQ in mp all fold to me I call as I know he is aggressive everyone folds to Villain who reraises to £15 I call. Flop comes 646r he blind raises £20 I have probably played around 100 hours with this villian and never before seen him do this move. I call the £20 turn comes 9 two spades he raises £35 I flat call river comes K he raises £75 I fold. I think I have played this terribly bad whats your thoughts?

As played we are playing a guessing game. You should have an idea what kind of hands this vilain 3 barrels with after 100 hours. This runout is good for our hand and we heavily underrepresented it. I would call barring reads that one pair is never good against his 3rd barrel.

Hand was played too passive imo. Raise preflop to get value from vilain + rest of the table and put yourself in a situation to play for stacks on good runouts. With the 5£ straddle your have 60BB with a big pair, in position.

If I'm limping pre-flop it's always with the intention of 3betting. If you think he's going to fold to your 3bet, then you probably make more money raising (knowing he's always calling), and letting him make mistakes on future streets where you can potentially stack him.

You should be calling this river if you're going to call the turn, unless you have reason to believe V isn't capable of bluffing this spot.

You are using the wrong terms. Villain raised pre, not re-raised and then he bet flop, bet turn, and bet river. Also, I assume you meant he bet $20 in the dark before the 646 flop was flipped over.

Raise pre, don't limp this hand.

Raise pre, preferably in the neighborhood of 30. If you go 35, you could get stacks in by the turn (you'd need a good idea of his calling range at this price). Make the villain put in more to play this hand. Since you knew he was going to raise, you should have 3-bet him to 50-60. Either way, a larger raise size pre makes this hand much easier for you to play.

If you're sure he will raise his straddle, I love the limp, but only if you're going to raise. I don't understand why you would limp and then just call. I'd default to raising pre, with limp/raising my second option. I'd never limp and then flat call a raise here. It doesn't seem like you had any plan for this hand.
As played, why wouldn't you raise flop? Ok, you're going to let him hang himself and you're not worried about an A or K peeling (I guess, not a lay I'd make). But then how do you not raise the turn? The 9 is a great card to raise.
River K, he bets and you fold. Well, this is partly why you should rais pe flop or turn, to reduce the odds you give him to draw to a random K.
But how many Kx hands are in his range here, with how this was played?
With how weakly you played this, your hand is under-repped. You have to call the river after just flat calling every opportunity up to this point.
But I don't like any street here.
Open raise pre flop or limp raise pre flop.
Raise the flop bet.
Or, raise the turn bet.
On the river, you're getting nearly 3 to 1 to call. Can't fold here getting 3 to 1, esp with how passively you played this.

Limping in seems fine to me given your experience of the villain. What you're really hoping for is a few more limps, maybe a small raise somewhere along the line, then villain comes in for a big raise. Then you make a huge reraise and take it down. Tidy little profit from QQ in MP.

That didn't happen, but it seems clear to me that you should still put in a nice re-raise, and be prepared to raise or re-raise on the flop.

Against this villain, you want to play this hand like it's AA. In other words, you need to assume that you're well ahead but that it's vulnerable.

You have to pray he doesn't have KK or AA ... but given his playing style, if he does have one of these hands, you can pay him off. That's his reward for all the times he spews cash by being too aggressive.