Genuinely curious to see some responses. I'm generally never folding these in live $1/$2 as the games I'm in are too loose to justify it, unless I have some extraordinary read like Villian hasn't played a hand in 4-5+ orbits.

I'm asking because online I find it much easier since I have stats. And even then I'm not sure.

Take for example $0.50/$1 online cash hand.

I have Q Q UTG+1

Raise 2.5x to open.

LJ 3-bets to 7BB.

SB 4-bets to 21BB.

SB has a stat line of VPIP 11 / PFR 9 over 280+ hands. Notes are that he has 4B only with AA before.

This was an "easy" fold (folding QQ is never easy for me but in this situation I didn't hesitate).

I feel as though sometimes I might be losing value here though, thoughts?

Effective stacks matter a lot here. Given live players' tendencies, I'm usually folding those hands to a cold 4-bet. Haven't played OL in a long time, but I'd usually GII with these holding pretty comfortably back in the day. Cold 3 and 4-bets might give me pause, though.

How many players at this table? It can't be 7-handed since then LJ=UTG+1.
In a full-ring 9-max game this is an easier fold than in a 8-handed game.

To answer your question in general, for live play, the answer is....it depends on configuration of raisers, and lots of other factors.

Re configuration: If I open BTN, SB 3bets, and BB 4bets, that's a much different situation than if I open UTG, UTG+1 3bets, and BB 4-bets. In the first situation (assuming std 100bb stacks), I'd be more inclined to jam with QQ/AK. In the latter situation I'd think it's an easy fold (assuming BB isn't suicidal).

Of course most players at 1/2, 1/3, 2/5 are super tight and are only 4-betting a range of KK+ (and maybe AK), and then it's just a fold with QQ/AK irrespective of the configuration.

Deep, against an unknown rec, we should fold to cold 4-bets. This is nearly always AA/KK. Sure occasionally they'll show up with something like AQ or JJ or some crazy bluff, but never at a frequency that's good enough for us.

Even against a 4-bet reraise by original bettor (that's different than a cold 4 bet, right?), you should fold sometimes.

For example, 100 stacks, 1/2, UTG (terrible player, transparent) raises to 15 (standard in our home game)...I make it 45 in CO with QQ. Folded to UTG who shoves for remaining stack.

Even though it's only 55 to me, I know he has AA/KK...but, for $55 into what will be a $203 pot, I'm only losing about 15 on the call (math right?).

One thing about small stakes is sometimes you just don't care and make "bad" poker decision, but fun "gambling" decisions!

Yes, I think any 4-bet at 1/2 1/3, we should assume AA/KK unless it's short stacked or we have reason to assume otherwise.

What all this adds up to, OP, is that you should be much more willing to fold QQ/AK at live 1/2 than online. Lots of LLSNL players are passive enough such that often 4b will be almost exclusively AA/KK. They're a level of loose passive that you don't run into much online (because online they'd get quickly wiped out).

Thanks for all the responses. This is interesting to me because it seems the live $1/$2 cash game locally here is maybe non-standard? In that I'm seeing very loose and splashy play frequently. I'm generally going Friday/Saturdays so there are a lot of tourists/gamblers so maybe thats why my "data" is skewed. I've seen JTs, 55, AJo, etc all shoved preflop recently. Maybe I'm having selective memory

1) Where are you playing and how deep does it play?
and
2) Were those cold 4-bets? I've seen that sort of 4-bet shove sometimes when the opener doesn't believe a three-bettor and tries to "re-steal," but pretty much never anything other than a super-premium when it is a cold 4-bet and for less than a shove.

Seminole Hard Rock -- and yeah you are right. I misread. Cold 4-bets are different, these were all 4B shoves. Thanks Garick!

It all depends. I've played in crazy gambool games where QQ was a dream come true if there's a cold 4 bet in front of you. Other times, it's the worst thing in the world because it's painful to lay down even though it's obviously no good. I've noticed even at micro stakes online a 4 bet that isn't an all in is usually AA/KK leaning toward only AA. FWIW, this seems universal.

If a villain hasn't played a hand in 4 orbits in live poker, that's not even close to an extraordinary read it's like way way far from it.

Once you start to say you will never do this or hardly ever to that blindly with no hand specifics is not how to be thinking about a live game, no matter how "loose" the table is. Your hand decisions should be player dependent, not table dependent.

Your example is for an online game which is different than a live game, but if it was live, a 4bet from an unknown usually has QQ and AK crushed. It's usually aces or kings like 80%+, without knowing any information on them.

You have vpip stats for the guy? Is this online?

Have folded these a bunch of times preflop in live games, especially AK. QQ is a snap fold to a 4bet against almost any villain in my games, AK is a fold to a 3bet against some villains. A couple of times I've sat there and almost made a frustrated call, then sadly folded, then got shown the rockets.

This is a bad example. We are getting 3.7:1 on our money. He has 50bb and even if the guy is super nitty he’s going to sometimes play JJ, 1010, AK this way. I’m not even throwing in the random spazz factor which 95% of players have.