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Can this spot be more important to handle beside just cards, GTO and equity calculation?
yeah, most low stakes players are so tight that this can be a fold but if you are totally readless, you can very comfortably 4b/c. I'm not used to playing 80BBs anymore, so I instantly flat at about 200BBs. That's a much more solid play. It's the size of the stack we have that is the most important factor.
Flatting at this stack size is terrible but at 200BBs or so it can be the right play. If you have reads that they are this tight it's a fold but you can 4bet call up to about 100 bigs if my math is correct. don't feel like doing all the math of it but you have pretty much the perfect stack to 4b/c vs any range. Good shortstacking strategy imo