I'll take a stab here:

Card edge, initiative, and skill advantage.

Now, to be fair, Snowie folds A2s to 9x raises. Actually, she folds just about everything to a 9x raise, but ... given the villain has opened for $45 for four orbits on the button, I think it's reasonable to believe he's not only playing AK here. Snowie will 3-bet A2s vs a 36% opening range. I think we can assume villain is wider than that.

I like a 3-bet, then look to C-bet numerous dry flops, any backdoor flush, and barrel the turn if your equity improves. If boards like QT7s or T74s appear, and you have none of it, I would be cautious. Mid suited cards tend to hit a wide opening/calling range with remarkable consistency. 1/2 pot bets should suffice through the ordeal.

This all assumes heads-up play. Fold to a 4-bet, obviously.

JMHO

(disclaimer: My money was made shortstacking. I have only recently decided to incorporate GTO-inspired AI play into deep stack, live environments. This may well be folly)

What range does villain 3 bet EIGHT times the original bet pre?

AA, KK, QQ, AK, maybe JJ? Hero has some equity against that range, but could be crushed.

As played, I'd flat and see a flop and re-evaluate since we are deep.

Its a 3blind hand so villains raise is to 4.5x and there is a bit of dead $, im sure snowie will still fold but he is wide here...he wants the dead straddle

A2s is def ahead of his open but he never folds 3bets so there will be a tom of flops i cant bet

For example, i once 3bet him with KK.and the flop was J88 and he had J8o. Im not comfortable cbetting 75% of flops

That hand happened 2 years ago and he hasnt changed his ways