2-5 NL, effective stacks are about $800

Villain is a good regular, also plays 5-10. Generally LAG and unpredictable, but still seems patient when card dead.

I have a little bit of history vs Villain, but it is from a while ago and he probably perceives me as a tight, semi-aggressive player. I've been in the game for a few hours at this point, but villain has only been in a couple orbits.

Villain raises to 15 UTG, 2 callers, I have QQ in CO and reraise to $65. Folds to villain who 4-bets to $185. Folds to Hero.

Hero ???? ($280 in pot)

I think if I just call, Villain will blast most flops and I'll be panicking but will probably pay off most hands because hey it's Queens.

If I reraise, how much? Villain has about $600 behind, I have him covered.

I think villain could have a wide 4-bet range here if he wanted to get it HU or even try to drive me out, the game is loose enough where there's a good chance one or both original callers will follow him for $65 and he will be in bad position.

Call

If Villian sees us as tight, there's a good chance his 4-bet range is AK,KK,AA.

We are 55-45 ahead of AK and way behind AA and KK.

If your read is good enough to include TT and JJ in his range, we might be 50-50 or so against his range.

(Only one QQ combo left, not really a factor in the decision.)

Without TT and JJ in his range we are hurtin' for certain IMHO.

Since this is someone you have played with, the correct play is going to depend on the dynamic between hero and villain. What has V showed up with in the past when he 4-bet? What has hero's 3-betting range been in sessions where V has been at the table?

He's denying you odds to call and try to flop a queen. If an unknown sat down at my table and 4 bet in this spot, I would fold.

This,

Although I will say that adding JJ/TT in his range is optimistic, I have no idea why a solid lag would ever want to 4bet ISO a tight player OOP with JJ/TT.

If anything he wants to flat and hope the others behind him overcall so he has better mining odds.

Can't imagine why hes ever making a move here unless he is spazzing out. I dump the hand.

Fold. If he's a good LAG, he knows he's OOP and good LAGs look to play big pots in position. OOP he should have it, and I'd give him credit for having it until proven otherwise. Maybe you fold the best hand or avoid a flip but if he is a good, tough LAG, look for better spots vs. him because this pot is headed towards playing for stacks. Nothing wrong with avoiding marginal situations against a tough player.

What was your plan for his possible 4-bet? Don't get caught off guard by playing on autopilot.

Why 3b so small? Would villain see that as weakness?

+1 with everything said...let it go and wait for a better spot.

Has $15 been a normal preflop bet? If not, he most likely did it with AA or KK and was looking for a raise. Small outside chance he's doing this with AK, most likely suited.

I would still call and see what the flop brings.