1/2 NL weekly home game rake free with $200 max buy in
40-60 yr old MAWGs
Hero effective stack $560 and covered by villains who are both LAGs
Hero in game for $500 and has tighten his rains and showing a profit after 6 hrs of play

Hero on button with AdQd
Button: UTG, UTG+1, MP, MP1, MP2, CO call 2
Hero makes it $20

MP2, CO call (72)
2d 4c 5d

MP2 bets 35, CO raises 110, hero?

Tell us about V. Does he have a raise/fold range? Will he pay off a flush if you flat? Are A's and Q's ever outs for you here?

I would lean towards a call given, you're in position, calling would entice MP to call, and if we're up against a value hand(sets and straights) you'd need to hit your flush or the 3 to possible chop A3. I think 36 is pretty unlikely given you raised pre but I've seen crazier. If CO is bluff raising/semi bluffing thinking you as the PFR missed this board and MP can't really call with less than a set/straight/FD then you want to just call and let him continue bluffing/semibluffing OTT. With both of these in mind you'd want MP to call to give you better odds to hit your flush so calling would be the play. You would also call if CO is bluffing to let him continue ,which is not as likely but still possible. If you shove OTF you're only getting called by sets and straights which is bad for you. Another plus to calling is that it keeps MPs and possibly even COs worse FDs in which is a huge payoff if you hit.

Call

Calling seems fine.

Also, I think you mixed your metaphors. One either "takes the reins," or "tightens the screws."

I think I make a tight fold on the flop but it's close. Mostly because it's easy for hero to make large mistakes on turn, while folding flop is unlikely to be more than a small mistake (absent more reads)

Folding flop is out of the question. That's almost the best flop you can get with AQs, what else are you hoping for?

Villian plays ATC. Had a discussion with him earlier in the week where he thought opening from UTG to 15 with 36s was profitable. He enjoys playing large pots and is either stuck 1-2k or up 1-2k. Lifetime he’s is down, -$5 per hour over 350 hours since tracking.

This player has seen me fold many times to large bets over the past 10 years. His large bets take down numerous pots throughout the night. I believe A&Q are possible outs.

I call the 110 and MP2 also calls. (402)

At this point, I put the CO on a set or overpair 6s-10s and MP3 on an overpair as he would raise with a set.
-18 outs: 9 diamond outs, (3) A, (3) Q , (3) 5
- JJ+, AQ+ would have raised preflop.

Turn: 3s giving us the straight.
MP2 checks, CO bets $325
Pot is now $727, hero has $430.

Hero?

At this point we shove - straight is not the nuts but if an A or a Q really was an out we got there.

And we have a redraw as well.